T Cell Differentiation L6

Question 1

What does the TCR complex consist of?

Answer 1

TCR + CD3 + Zeta

Question 2

What does CD3 do?

Answer 2

Transduces signals along with zeta and will send message to nucleus

Question 3

What is a marker of T cells?

Answer 3

CD3+

Question 4

What are the two things that T cells can differentiate to?

Answer 4

Alpha-Beta TCR + CD3+

Gamma-Delta TCR+ CD3+

Question 5

Which one is the major T cell population?

Answer 5

Alpha Beta TCR CD3

Question 6

What can the Major T cell population differentiate to?

Answer 6

CD4+

CD8+

Question 7

Which CD is more in terms of number?

Answer 7

CD4+

Question 8

The ration between CD4/CD8 is an indicator of what?

Answer 8

Sickness

Question 9

What do T cells respond to?

Answer 9

Pathogen or proteins that get into the host cell via infection

Question 10

Why do we need T cells?

Answer 10

• When pathogens enter, B cells are useless

- T cells are needed to deal with them intracellularly

Question 11

Which MHC class interacts with CD8+ cells?

Answer 11

Class I

Question 12

Which MHC class interacts with CD4+ cells?

Answer 12

Class II

Question 13

What are the functions of CD4+ and CD8+ receptors?

Answer 13

1. Specific adhesion molecules

2. Enhance signal through TCR

Question 14

What type of cells does HIV infect?

Answer 14

CD4+

Question 15

T/F CD4 & CD8 are exclusively part of T cells

Answer 15

FALSE

Question 16

Antigen Recognition is brough by _____

Answer 16

Alpha Beta or Gamma Delta

Question 17

Signal Transduction is associated with _____.

Answer 17

TCR + CD3 + Zeta

Question 18

The coreceptors of T cells are _____

Answer 18

CD4 & CD8

Question 19

Can T cells class switch like B cells?

Answer 19

NO

Question 20

What disease can be caused by abnormal T cell development?

Answer 20

Di George’s Syndrome

Question 21

What happens if you allow self cells to be sent out of the thymus?

Answer 21

Autoimmune disease