Antigen Presenting Cells L5

Question 1

What receptor binds to the APC and makes it active?

Answer 1

Toll Cell Receptor (TCR)

Question 2

What is TCR?

Answer 2

Recognizes Pathogen Associated Molecular Patterns (PAMP)

Question 3

After APC is activated, what happens next?

Answer 3

Cytokine production

Question 4

The production of cytokines induces what?

Answer 4

IL-1 & TNF

Question 5

What three things are considered APC?

Answer 5

1. Dendritic Cells
2. Macrophages/Monocytes
3. B-lymphocytes

Question 6

What types of cytokines are involved (5)?

Answer 6

1. Chemotines
2. IFN Alpha & Beta
3. IL-6
4. IL-12
5. IL-10

Question 7

What are chemotines?

Answer 7

Chemotactic cytokines

Question 8

What are IFN Alpha & Beta?

Answer 8

Antiviral

Question 9

What does IL-6 do?

Answer 9

Activates bone marrow causing an increase in WBC

Question 10

What does IL-12 do?

Answer 10

Activates TH1 cells and NK cells

Question 11

What does IL-10 do?

Answer 11

Inhibitory cytokines therefore decreases immune responses

Question 12

What does APC do to the antigen?

Answer 12

Cuts it up to pieces and presents it to the T cell

Question 13

What are the three functions if IL-1 and TNF?

Answer 13

1. Increase stickyness of endothelial cells -> inflammation
2. Activation of liver to release proteins (CRP)
3. Effect hypothalamus –> Fever, depression, anorexia

Question 14

Where is MHC located?

Answer 14

On chromosome #6

Question 15

What is MHC equivalent to?

Answer 15

HLA

Question 16

What does Class I MHC consist of?

Answer 16

HLA A,B,C

Question 17

T/F Class I MHC is not present in all nucleated cells

Answer 17

FALSE: It is present in ALL nucleated cells (RBC is not nucleated therefore does not have Class I)

Question 18

What does Class II MHC consists of?

Answer 18

HLA DP, DQ, DR

Question 19

Where are Class II MHC located?

Answer 19

ONLY on APC

Question 20

T/F Class II MHC have alpha and Beta chains while Class I MHC have a single Alpha Chain

Answer 20

True

Question 21

What defect does one have if one suffers from Ankylosing Spondylitis?

Answer 21

HLA B 27 (CLASS I)

Question 22

What defect does one have if one suffers from Narcolepsy?

Answer 22

DR2 + DR1 (CLASS II)

Question 23

What defect does one have if one suffers from Type I Deabetus Mellitus?

Answer 23

IDDM DR3 OR DR4 (CLASS II)

Question 24

What defect does one have if one suffers from Rheumatoid Arthitis?

Answer 24

HLA DR 4 (CLASS II)

Question 25

What does IL-8 do?

Answer 25

Attract other cells during inflammation

Question 26

If your C-Reactive Protein (CRP) is reduced, what does that tell you?

Answer 26

Very sick

IL-1 and TNF have been reproduced

Question 27

T/F MHC genes are co dominantly expressed

Answer 27

TRUE