Antigen Presenting Cells L5 Flashcards
What receptor binds to the APC and makes it active?
Toll Cell Receptor (TCR)
What is TCR?
Recognizes Pathogen Associated Molecular Patterns (PAMP)
After APC is activated, what happens next?
Cytokine production
The production of cytokines induces what?
IL-1 & TNF
What three things are considered APC?
- Dendritic Cells
- Macrophages/Monocytes
- B-lymphocytes
What types of cytokines are involved (5)?
- Chemotines
- IFN Alpha & Beta
- IL-6
- IL-12
- IL-10
What are chemotines?
Chemotactic cytokines
What are IFN Alpha & Beta?
Antiviral
What does IL-6 do?
Activates bone marrow causing an increase in WBC
What does IL-12 do?
Activates TH1 cells and NK cells
What does IL-10 do?
Inhibitory cytokines therefore decreases immune responses
What does APC do to the antigen?
Cuts it up to pieces and presents it to the T cell
What are the three functions if IL-1 and TNF?
- Increase stickyness of endothelial cells -> inflammation
- Activation of liver to release proteins (CRP)
- Effect hypothalamus –> Fever, depression, anorexia
Where is MHC located?
On chromosome #6
What is MHC equivalent to?
HLA
What does Class I MHC consist of?
HLA A,B,C
T/F Class I MHC is not present in all nucleated cells
FALSE: It is present in ALL nucleated cells (RBC is not nucleated therefore does not have Class I)
What does Class II MHC consists of?
HLA DP, DQ, DR
Where are Class II MHC located?
ONLY on APC
T/F Class II MHC have alpha and Beta chains while Class I MHC have a single Alpha Chain
True
What defect does one have if one suffers from Ankylosing Spondylitis?
HLA B 27 (CLASS I)
What defect does one have if one suffers from Narcolepsy?
DR2 + DR1 (CLASS II)
What defect does one have if one suffers from Type I Deabetus Mellitus?
IDDM DR3 OR DR4 (CLASS II)
What defect does one have if one suffers from Rheumatoid Arthitis?
HLA DR 4 (CLASS II)
What does IL-8 do?
Attract other cells during inflammation
If your C-Reactive Protein (CRP) is reduced, what does that tell you?
Very sick
IL-1 and TNF have been reproduced
T/F MHC genes are co dominantly expressed
TRUE
