INTRACERLLULAR COMMUNICATION Flashcards
can be defined as the communication that
takes place within the cell.
Intracellular communication
The basis for the coordination of the physiological functions within a
multicellular organism is
intercellular signaling
Cells communicate through chemical signals, these chemical signals are
known as
ligands.
also called lipid-soluble ligands, can directly diffuse
through the plasma membrane and interact with internal receptors.
hydrophobic ligands
bind to the
extracellular domain of cell-surface receptors.
Water-soluble ligands
within the target cell must be coordinated, fine-tuned
and channeled within a network of intracellular signaling paths that finally
trigger distinct biochemical reactions and thus determine the specific functions
of a cell
Signal transduction
Tool for Intracellular Signaling (2)
Extracellular messengers
Gap junctions
Cells send out signals in the form of specific
messenger molecules that the target cell transmits into a biochemical
reaction.
Extracellular messengers
are channels that connect
two neighboring cells to allow a direct exchange of metabolites and signaling
molecules between the cells.
Gap junctions
Tool for Intracellular Signaling (2)
Cell–cell interaction via cell-surface proteins
Electrical signaling
A further intercellular communication mechanism relies
on electrical processes.
Electrical signaling
Another form of direct
communication between cells occurs with the help of surface proteins.
Cell–cell interaction via cell-surface proteins
Features of Cell Signaling (4)
Specificity
Amplification
Desensitization
Integration
the complementarity of structure between ligand and receptor binding contributes to the high specificity of the signaling pathway.
Specificity
During intracellular communication, the signal amplifies
several folds to generate the response.
Amplification