Carbohydrate Metabolism Flashcards
The formation of new glucose molecules form noncarbohydrate precursor
Gluconeogenesis
Primarily occurs in liver
Gluconeogenesis
Secondarily occurs in kidneys
Gluconeogenesis
gluconeogenesis originates in the liver or kidneys cytoplasm or mitochondria
Gluconeogenesis pathways
From pyruvate requires two enzymes
Pyruvate carboxylase
PEP carboxykinase
Found within mitochondria, converts pyruvate to oxaloacetate (OAA)
Pyruvate carboxylase
Found only in liver and kidney, catalyzed the irreversible hydrolysis
Glucose-6-phosphate
Each of the foregoing reactions is marched by an opposing irreversible reaction in glycolysis.
Each set of such paired reactions is referred to as a
Substrate Cycle
Regulating of the flow of substrate and removal of product
Flux control
Is more effective if transient accumulation of product is funneled back through the cycle
Flux control
Lactate is released by skeletal muscle during exercise
Cori Cycle
A product for fat metabolism in adipose tissue, is transported to the liver in the blood
Glycerol
Are amino acids that can be converted into glycolytic intermediate
Glucogenic molecules
Are catabolized into citric acid cycle metabolites such as Alpha-ketoglutarate
Glucogenic amino acids
The rate of gluconeogenesis is affected primarily by substrate
Gluconeogenesis regulations