intracellular bacteria Flashcards
name 3 obligate intracellular parasites
rickettsial
chlamydia
viruses
name 7 facultative intracellular parasites
cocci enterics mycobacteria bacilli listeria legionella fungi
name 3 parasites that use type 3 secretion systems
enterics, legionella, mycobacter
name 2 bacteria that use actin based motility
listeria, shigella
how do enterics evade the humoral immune system
use of M cells as gateway to exterior surface of intestine
works around colonization resistance and tight junctions on interior surface
listeria characteristics (5)
gram + rod facultative anaerobic beta hemolytic tumbling motility grows in cold
who does listeria primarly infect?
fetus across placenta
newborns during delivery
pregnant women
immunocompromised adults
how does listeria present in a pregnant person
abortion, premature delivery, postpartum sepsis
how does listeria present in new born
menigitis
how does listeria present in immunocompromised adult
sepsis or meningitis
how does listeria present in previously healthy person?
gastroenteritis (self limiting)
rickettsial characteristics (3)
very short rods hard to gram stain but (-)
vectored by tics
obligate intracellular parasites
rocky mountain spotted fever virulence factor
invade and multiple in vascular endotheium
leading to characteristic rash due to leaky blood vessels
rocky mountain spotted fever symptoms
headache, fever, myalgia, vasculitis, rash, progresses to delirium, coma, DIA
diagnosis of rocky mountain
immunochemical tests available
can see bug in skin biopsy
why is the life cycle of chlamydia trachomatis unique?
involves 2 cell types
dense rugged elementary bodies attach to cell, endocytosis, survive and become reticulate bodies which are larger and delicate. the RBs replicate and metabolize
difference between elementary bodies and reticular bodies
EBs are infectious
RBs divide
genital chlamydia symptoms in males
urethral discharge, dysuria, scrotal pain
genital chlamydia symptoms in females
mucopurulent endocervical discharge, bleeding, dysuria, abdominal pain, progression to PID
risk to both genders in genital chlamydia
reiter syndrome (reactive arthritis)
genital chlamydia infection presentation in infants
ocular trachoma
2 diagnostic methods for chlamydia
- culture
2. molecular method (more likely to give false positive)
