intracellular bacteria

Question 1

name 3 obligate intracellular parasites

Answer 1

rickettsial
chlamydia
viruses

Question 2

name 7 facultative intracellular parasites

Answer 2

cocci
enterics
mycobacteria
bacilli
listeria
legionella
fungi

Question 3

name 3 parasites that use type 3 secretion systems

Answer 3

enterics, legionella, mycobacter

Question 4

name 2 bacteria that use actin based motility

Answer 4

listeria, shigella

Question 5

how do enterics evade the humoral immune system

Answer 5

use of M cells as gateway to exterior surface of intestine

works around colonization resistance and tight junctions on interior surface

Question 6

listeria characteristics (5)

Answer 6

gram + rod
facultative anaerobic
beta hemolytic
tumbling motility
grows in cold

Question 7

who does listeria primarly infect?

Answer 7

fetus across placenta
newborns during delivery
pregnant women
immunocompromised adults

Question 8

how does listeria present in a pregnant person

Answer 8

abortion, premature delivery, postpartum sepsis

Question 9

how does listeria present in new born

Answer 9

menigitis

Question 10

how does listeria present in immunocompromised adult

Answer 10

sepsis or meningitis

Question 11

how does listeria present in previously healthy person?

Answer 11

gastroenteritis (self limiting)

Question 12

rickettsial characteristics (3)

Answer 12

very short rods hard to gram stain but (-)
vectored by tics
obligate intracellular parasites

Question 13

rocky mountain spotted fever virulence factor

Answer 13

invade and multiple in vascular endotheium

leading to characteristic rash due to leaky blood vessels

Question 14

rocky mountain spotted fever symptoms

Answer 14

headache, fever, myalgia, vasculitis, rash, progresses to delirium, coma, DIA

Question 15

diagnosis of rocky mountain

Answer 15

immunochemical tests available

can see bug in skin biopsy

Question 16

why is the life cycle of chlamydia trachomatis unique?

Answer 16

involves 2 cell types
dense rugged elementary bodies attach to cell, endocytosis, survive and become reticulate bodies which are larger and delicate. the RBs replicate and metabolize

Question 17

difference between elementary bodies and reticular bodies

Answer 17

EBs are infectious

RBs divide

Question 18

genital chlamydia symptoms in males

Answer 18

urethral discharge, dysuria, scrotal pain

Question 19

genital chlamydia symptoms in females

Answer 19

mucopurulent endocervical discharge, bleeding, dysuria, abdominal pain, progression to PID

Question 20

risk to both genders in genital chlamydia

Answer 20

reiter syndrome (reactive arthritis)

Question 21

genital chlamydia infection presentation in infants

Answer 21

ocular trachoma

Question 22

2 diagnostic methods for chlamydia

Answer 22

1. culture

2. molecular method (more likely to give false positive)