INTERMEDIATE FILAMENT MARKERS Flashcards
It is a sensitive marker for muscle differentiation and can be used to identify tumors derived from smooth, skeletal and cardiac muscle
A. Desmin
B. Vimentin
C. ACTIN
D. GFAP
C. ACTIN
VIMENTIN MARKER
A. 58kd
b. 51kd
c.57kD
c.57kD
Desmin marker
A. 58kd
b. 51kd
c.57kD
d. 53kD
d. 53kD
intermediate filament that is present in normal mesenchymal cells and
their neoplastic counterparts (i.e., sarcoma, melanoma, lymphoma,
leukemia, seminoma, and some neural tumors).
A. 58kd
b. 51kd
c.57kD
d. 53kD
c.57kD
Melanomas and Schwannomas always stain positive
a. actin
b. vimentin
c. GFAP
d. desmin
b. vimentin
intermediate filament expressed by smooth and striated (skeletal and
cardiac) muscle
A. 58kd
b. 51kd
c.57kD
d. 53kD
d. 53kD
It is considered to be highly specific for myogenic tumors, including
leiomyoma (smooth muscle tumor) and rhabdomyosarcoma (skeletal
muscle tumor)
a. actin
b. vimentin
c. GFAP
d. desmin
d. desmin
It is also used to demonstrate the myogenic component of mixed tumor
a. actin
b. vimentin
c. GFAP
d. desmin
d. desmin
intermediate filament protein expressed by central nervous system
glial cells, particularly astrocytes.
A. 58kd
b. 51kd
c.57kD
d. 53kD
b. 51kd
It is most widely used to confirm the diagnosis of astrocytoma
A. 58kd
b. 51kd
c.57kD
d. 53kD
b. 51kd
Non-CNS tumors (meningiomas, metastatic carcinomas and lymphomas)
stain
A. NEGATIVE FOR 53KD
B. POSITIVE for GFAP.
C. negative for GFAP.
D. POSITIVE FOR CEA
C. negative for GFAP.
Expressed in cells of neural origin, particularly neurons, neuronal processes, peripheral nerves, sympathetic ganglia, adrenal medulla and neuroendocrine cells
A.Neurofilament (NF)
B. S-100 protein
C. Chromogranin
Neurofilament (NF)
Low molecular weight calcium-binding protein
A.Neurofilament (NF)
B. S-100 protein
C. Chromogranin
B. S-100 protein
