EPITHELIAL TUMOR MARKERS Flashcards
Frequently found in carcinomas of the lung, breast, uterus and ovaries (serous tumors). These tumors are typically negative for CK20.
A. KERATIN
B. CK20
C.CEA
D.CK7
D.CK7
Highly sensitive marker for epithelial cells and is present in epithelial
tumors (carcinoma)
A. KERATIN
B. CK20
C.CEA
D.CK7
A. KERATIN
Mesotheliomas & Non - seminomatous germ cell tumors
A. KERATIN
B. CK20
C.CEA
D.CK7
A. KERATIN
Renal cell carcinomas, hepatocellular carcinomas, prostatic
adenocarcinomas, thyroid carcinomas and squamous cell carcinomas
(skin, lung and esophagus)
A. usually negative for CK7
b. usually negative for either CK7 or CK20
c. usually positive for CK7
d. usually negative for ck20
b. usually negative for either CK7 or CK20
More common in carcinomas of the colon and stomach. These tumors are usually negative for CK7.
A. KERATIN
B. CK20
C.CEA
D.CK7
B. CK20
Transitional cell carcinomas of the bladder and mucinous ovarian
A. usually negative for CK7.
B. Positive for both CK7 and CK20
C. usually negative for either CK7 or CK20.
B. Positive for both CK7 and CK20
High molecular weight protein that is helpful in determining the site of
tumor
A. CEA
B.PSA
C.TTF-1
D. EMA
D. EMA
positive for adenocarcinomas of the breast, lung and kidneys.
A. CEA
B.PSA
C.TTF-1
D. EMA
D. EMA
Non-reactive for hepatocellular carcinomas, adrenal carcinomas or
embryonal carcinomas, and negative for non-epithelial tumors
A. CEA
B.PSA
C. EMA
D.ACTIN
C. EMA
Useful in distinguishing lung adenocarcinomas from mesotheliomas
A. CEA
B.PSA
C.TTF-1
D. EMA
C.TTF-1
An oncofetal antigen that is present in carcinomas of the gastrointestinal
tract, pancreas, lung, breast, ovary, uterus and cervix.
A. CEA
B.PSA
C.TTF-1
D. EMA
A. CEA
It is positive in thyroid, lung and neuroendocrine tumors (medullary
thyroid carcinomas, carcinoid tumors and small cell tumors of the lung).
A. CEA
B.PSA
C.TTF-1
D. EMA
C.TTF-1
useful in the diagnosis of prostatic adenocarcinoma. It is also positive in
certain pancreatic and salivary gland tumors
A. CEA
B.PSA
C.TTF-1
D. EMA
B.PSA