interleukins Flashcards
1
Q
- “monocyte-derived neutrophil chemotactic factor”
- inflammatory cytokine for NEUT and T cells
A
IL-8
2
Q
- “B cell stimulating factor-1”
- early activation of resting B cells
- promotes production of IgG2 and IgE
A
IL-4
3
Q
- possesses many biologic effects similar to IL-4
- (macrophage) inhibits their activation
- antagonize IFN-gamma
A
IL-13
4
Q
- can induce cells of immune system to secrete TNF-a
- involved in activation induced cell death
A
IL-32
5
Q
- “Interferon beta-2” or “B cell stimulating factor-2”
- induces secretion of immunoglobulin
- induction of the acute phase reaction
- produced by both lympoid and nonlymphoid
- expressed in T and B cells
A
IL-6
6
Q
- “lymphopoietin-1”
- stimulates early B cell progenitor cells
A
IL-7
7
Q
- “T cell growth factor”
- initiate proliferation or clonal expansion of activated T cells
- dramtically enhances cytolytic activity
A
IL-2
8
Q
biologically similar to IL-2
A
IL-15
9
Q
- inhibits cytokine synthesis in various cells
- anti-inflammatory and suppressive effects on TH1 cells
- inhibits antigen presentation
- stimulates CD8+ T cells
- induces production of MHC II on B cells
A
IL-10
10
Q
role on immunse defense against viruses
A
IL-28
11
Q
- “B cell growth factor-2”
- not active on early lymphoid cells
A
IL-5
12
Q
- recently dicovered cytokine
- shares some in vivo functions qith IL-12
- activation of STAT 4
A
IL-23
13
Q
- enhance activity of cytotoxic effector T cells
- growth factor for NK cells and T cells
A
IL-12
14
Q
- regulates hematopoiesis and immune response
- influences development of lymphocytes
- similar to IL-2 and IL-15 in anti-tumor defense
A
IL-21
15
Q
- predominantly released by and acts on nonhematopoietic tissues
- role in wound healing and cancer
A
IL-24
16
Q
- “multi-colony stimulating factor”
- promotes growth of early hematopoietic cell lines
A
IL-3
17
Q
acts as a B cell growth factor
A
IL-14
18
Q
potent lymphocyte growth factor
A
IL-9
19
Q
induces rapid phosphorylation of transcription factors STAT-1 and -3
A
IL-26
20
Q
believed to play role in skin inflammation
A
IL-31
21
Q
similar to IL-10, but does not prohibit the production of proinflammatory cytokines through monocytes
A
IL-22
22
Q
- also called SF-20
- novel, secreted, bone marrow stromal-derived growth factor
A
IL-25
23
Q
- biologic function is similar to IL-10
- regulates functions of macrophages
- supresses T helper cells (TH1 and TH2)
A
IL-19
24
Q
- synergist with IL-12 (in some effects)
- stimulates productio of IFN-gamma by NK cells and T cells
A
IL-18
25
Q
- “lymphocyte-activating factor”
- activation of resting T cells
- “endogenous pyrogen”
- promotes diapedesis
A
IL-1
26
Q
important function in regulating activity of B and T lymphocytes
A
IL-27
27
Q
- role in host defenses against microbes
- gene is highly unpregulated in cells infected with virus
A
IL-29
28
Q
- chemoattractant
- participates in the regulation of cytokines
- mimics proinflammatory actions of a TNF-alpha & beta
A
IL-16
29
Q
- also called IL27p28
- an IL-27 heterodimer which triggers expansion of antigen-specific naive CD4+ positive T cells
A
IL-30
30
Q
- induces granulopoiesis through G-CSF
- increased by histamin and serotonin
- reinforce antibody-dependent tumor cell destruction
- participates in the regulation of cytokines
A
IL-17
31
Q
- regulator of hematopoiesis-stroma that stimulates production of megakaryocytes and myeloid progenitors
- increases the number of immunoglobulin-secreting B lymphocytes
A
IL-11
32
Q
important role in skin inflammation
A
IL-20
33
Q
induces type 2 cytokine production from Th cells
A
IL-33
