interleukins Flashcards
1
Q
- “monocyte-derived neutrophil chemotactic factor”
- inflammatory cytokine for NEUT and T cells
A
IL-8
2
Q
- “B cell stimulating factor-1”
- early activation of resting B cells
- promotes production of IgG2 and IgE
A
IL-4
3
Q
- possesses many biologic effects similar to IL-4
- (macrophage) inhibits their activation
- antagonize IFN-gamma
A
IL-13
4
Q
- can induce cells of immune system to secrete TNF-a
- involved in activation induced cell death
A
IL-32
5
Q
- “Interferon beta-2” or “B cell stimulating factor-2”
- induces secretion of immunoglobulin
- induction of the acute phase reaction
- produced by both lympoid and nonlymphoid
- expressed in T and B cells
A
IL-6
6
Q
- “lymphopoietin-1”
- stimulates early B cell progenitor cells
A
IL-7
7
Q
- “T cell growth factor”
- initiate proliferation or clonal expansion of activated T cells
- dramtically enhances cytolytic activity
A
IL-2
8
Q
biologically similar to IL-2
A
IL-15
9
Q
- inhibits cytokine synthesis in various cells
- anti-inflammatory and suppressive effects on TH1 cells
- inhibits antigen presentation
- stimulates CD8+ T cells
- induces production of MHC II on B cells
A
IL-10
10
Q
role on immunse defense against viruses
A
IL-28
11
Q
- “B cell growth factor-2”
- not active on early lymphoid cells
A
IL-5
12
Q
- recently dicovered cytokine
- shares some in vivo functions qith IL-12
- activation of STAT 4
A
IL-23
13
Q
- enhance activity of cytotoxic effector T cells
- growth factor for NK cells and T cells
A
IL-12
14
Q
- regulates hematopoiesis and immune response
- influences development of lymphocytes
- similar to IL-2 and IL-15 in anti-tumor defense
A
IL-21
15
Q
- predominantly released by and acts on nonhematopoietic tissues
- role in wound healing and cancer
A
IL-24
