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imse (prelim) > antibodies > Flashcards

antibodies Flashcards

1
Q

types of Ig

  • present in secretions;
  • tears, saliva
A

IgA

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2
Q

which Ig rects to the following temperature

  • (cold) reacts at 40 C to room temp:
  • (warm) reacts at 37 C
A
  • IgM
  • IgG
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3
Q

for any Ig molecule, only 1 type of (?) is present

A

light chain

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4
Q

antibodies produced after the introduction of the antigen from the same species

A

isoantibodies/alloantibodies

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5
Q

types of Ig

  • serum half life: 6 days
  • complement fixation: yes (best)
  • crosses placenta: no
A

IgM

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6
Q

bonds responsible to hold polypeptide chains

A

disulfide bonds

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7
Q

structure of Ab

all immunoglobulin milecules are made up of (?)-chain polypeptide units that consists of (?) large chains called (?), and (?) smaller chains called (?)

A
  • four
  • 2
  • heavy chains
  • 2
  • light chains
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8
Q

reaction with antigen

responsible for immobilization of motile organisms and for cell clumping

A

agglutinins

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9
Q

amino terminal or carboxyl terminal

  • variable region
  • responsible for antigen binding
A

amino terminal

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10
Q

types if Ig

  • serum half life: 23 days
  • complement fixation: yes
  • crosses placenta: yes
A

IgG

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11
Q

this is where the BENCE JONES PROTEINS are discovered

A

light chains

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12
Q

structure of Ab

elucidated in the 1950s and 1960, by:

A

gerald edelman & rodney porter

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13
Q

reaction with antigen

can cause agglutination of RBC

A

hemagglutins

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14
Q

isotype, allotype, or idiotype

heavy chains are unique to its immunoglobulin class

A

isotype

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15
Q

types of Ig

  • functions in immunoregulation
  • heat-labile; “anti-idiotypic antibody”
  • 2nd to appear on B cell surface
  • role on B cell maturation
A

IgD

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16
Q

isotype, allotype, or idiotype

genetic variation on the constant region

A

allotype

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17
Q

types of Ig

  • serum half life: 5 days
  • complement fixation: alternative pathway
  • crosses placenta: no
A

IgA

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18
Q

INTERCHAN or INTRACHAN BONDS

  • (normal) heavy chain to heavy chain/heavy to light chain (H-H/H-L): (?)
  • (abnormal) light chain to light chain (L-L): (?)
A
  • INTERCHAN BONDS
  • INTRACHAN BONDS
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19
Q
  • serves as a linkage points for disulfide bonds between 2 monomers
  • present on IgM and IgA
A

joining chain

20
Q

amino terminal or carboxyl terminal

  • constant region
  • determine the serological & physical chain of an antibody
A

carboxyl terminal

21
Q

heavy chains or light chains

  • 23,0000 da
  • has KAPPA & LAMBDA
A

light chains

22
Q

serum IgA or secretory IgA

  • dimer; “antiseptic paint”:
  • monomer; can’t fix complement:
A
  • seretory IgA
  • serum IgA
23
Q

heavy chains or light chains

  • determine Ig class (IgA, IgD, IgE, IgG, IgM)
  • 50,000 to 90,000 da
  • consists of 440 amino acid residue
A

heavy chains

24
Q

the folded domains of the H chains line up with L chains to produce a cylindrical structure called (?)

A

immunoglobulin fold / barrel

25
Q

subclass if IgG

  • cannot cross the placenta:
  • can cross the placenta:
  • cannot fix complement:
  • can fix complement:
A
  • IgG2
  • IgG1
  • IgG4
  • IgG3
26
Q

types of Ig

  • least abundant
  • “reagenic antibody”
  • “nuisance antibody”
  • heat labile
A

IgE

27
Q

major antibody in the secondary immune response

A

IgG (IgM is primary)

28
Q

antigen is captured within the barrel by binding to a small number of amino acids at strategic locations on each chain known as (?)

A

hypervariable region

29
Q

number of structure unit

  • composed of one structure unit:
  • composed of more than a single monomeric unit
  • composed of two structure unit:
  • composed of five structure unit:
A
  • momomer
  • polymer
  • dimer
  • pentamer
30
Q
  • substances produced in response to antigenic stimulation that are capable of specific interaction with provoking immunogen
  • serum factors in the blood formed in response to foreign substance exposure
  • can be visualized by electrophoresis
A

antibodies/immunoglobulins

31
Q

types of Ig

  • pentameric form
  • aka “macroglobulin”
  • “starlike” (free)
  • “crab-like” (combined)
  • primary immune response
A

IgM

32
Q

occurence of Ig

  • (natural) appear without any apparent stimulus:
  • (immune) appear following the introduction of an antigen:
A
  • IgM
  • IgG
33
Q

primary agents for fragmentation

A
  • PAPAIN
  • PEPSIN
34
Q
  • allows flexibility
  • absent in IgM and IgE
A

hinge region

35
Q

antibodies produced after the introduction of the antigen from another species

A

heterophile antobodies

36
Q

reaction with antigen

act upon bacterial invaders, weakening their resistance to the phagocytizing action of leukocyte

A

opsonins

37
Q

types of Ig

  • serum half life: 1-3 days
  • complement fixation: no
  • crosses placenta: no
A

IgD

38
Q

theories

he formulated the side-chain theory

A

paul ehrlich

39
Q

theories

he put forth a second major theory in the early 1900, the template theory

A

felix haurowitz

40
Q

reaction with antigen

agglutinins that are modified by heat in such manner that they can no longer bring out agglutination but still are capable of combining with specific agglutinogens

A

agglutinoids

41
Q

gerald edelman, rodney porter, alfred nisonoff

utilized PAPAIN

A

rodney porter

42
Q
  • KAPPA is encoded on:
  • LAMBDA is encoded on:
A
  • chromosome 2
  • chromosome 22
43
Q

theories

who made the clonal selection theory (most acceptable theory)

A

niels jerne & macfarlane burnet

44
Q

gerald edelman, rodney porter, alfred nisonoff

utilized PEPSIN

A

alfred nisonoff

45
Q

types of Ig

  • serum half life: 2-3 days
  • complement fixation: no
  • crosses placenta: no
A

IgE

46
Q

gerald edelman, rodney porter, alfred nisonoff

ultracentrifuge

A

gerald edelman

47
Q

isotype, allotype, or idiotype

genetic variation on the variable region

A

idiotype

imse (prelim) (6 decks)

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