cytokines Flashcards
1
Q
cytokines effects
affect the same cell that secretes it
A
autocrine
2
Q
TNF
- expressed in most tisues
- activated by soluble TNF-a
A
TNFR-1
3
Q
action of cytokines
different cytokines activates same pathways
A
redunduncy
4
Q
IFN
- activates NK cells
- enhance the expression of MHC class I proteins
A
INF type I
5
Q
TNF
- membrane bound form
- soluble form
- unstable
- short life
A
TNF-a
6
Q
induce chemokine production
A
- TNF-a
- IL-6
7
Q
TNF
- expressed in epithelial cells & cells of immune system
- expressed by membrane bound TNF-a
A
TNFR-2
8
Q
- interfere with viral replication
- produced by dendritic cells
- limit infection
A
IFN (interferons)
9
Q
INNATE or ADAPTIVE cytokines
- IL-2
- IL- 4
- IL-10
- IFN-gamma
A
ADAPTIVE
10
Q
INNATE or ADAPTIVE cytokines
- IL-1
- IL-6
- TNF- alpha
- INF-alpha & beta
- TGF-beta
A
INNATE
11
Q
cytokines effects
affects target cells on close proximities
A
paracrine
12
Q
action of cytokines
enhance effects
A
synergy
13
Q
- isolated in tumor cells
- has endocrine and paracrine stimuli
- kills tumor cells
A
TNF (tumor necrosis factor)
14
Q
major PROINFLAMATORY or ANTI-INFALMATORY cytokines
- TNF-alpha
- IL-1
- IL-6
- IFN-gamma
A
major proinflamatory cytokines
15
Q
action of cytokines
supress the action
A
antagonism
