cytokines Flashcards
cytokines effects
affect the same cell that secretes it
autocrine
TNF
- expressed in most tisues
- activated by soluble TNF-a
TNFR-1
action of cytokines
different cytokines activates same pathways
redunduncy
IFN
- activates NK cells
- enhance the expression of MHC class I proteins
INF type I
TNF
- membrane bound form
- soluble form
- unstable
- short life
TNF-a
induce chemokine production
- TNF-a
- IL-6
TNF
- expressed in epithelial cells & cells of immune system
- expressed by membrane bound TNF-a
TNFR-2
- interfere with viral replication
- produced by dendritic cells
- limit infection
IFN (interferons)
INNATE or ADAPTIVE cytokines
- IL-2
- IL- 4
- IL-10
- IFN-gamma
ADAPTIVE
INNATE or ADAPTIVE cytokines
- IL-1
- IL-6
- TNF- alpha
- INF-alpha & beta
- TGF-beta
INNATE
cytokines effects
affects target cells on close proximities
paracrine
action of cytokines
enhance effects
synergy
- isolated in tumor cells
- has endocrine and paracrine stimuli
- kills tumor cells
TNF (tumor necrosis factor)
major PROINFLAMATORY or ANTI-INFALMATORY cytokines
- TNF-alpha
- IL-1
- IL-6
- IFN-gamma
major proinflamatory cytokines
action of cytokines
supress the action
antagonism
major PROINFLAMATORY or ANTI-INFALMATORY cytokines
- TGF-beta
- IL-10
- IL-13
- IL-35
major ANTI-INFLAMMATORY cytokines
action of cytokines
domino effect
cascade induction
action of cytokines
single cytokines have different actions
pleiotropy
cytokines effects
systemic activity
endocrine
