Interleukins Flashcards
1
Q
Interleukins-
Types of preparations-
A
Aldesleukin (P)-
Human interleukin produced by recombinant DNA technology using e. coli bacteria
Oprelvekin-
A newer gent produced by DNA technology
2
Q
Interleukins-
MOA
A
- Increase the number of natural killer cells (NK cells) and lymphocytes
- Activates cellular immunity and inhibits tumor growth
3
Q
Interleukins-
Indications
A
Aldesleukin(P): Specific renal carcinomas, possible tx of AIDS and AIDS related d/o’s
Oprelvekin: Prevention of severe thrombocytopenia after myelosuppressive chemotherapy
4
Q
Interleukins-
Contraindications
A
Known allergy, preg/lact.
5
Q
Interleukins-
Cautions
A
Renal, liver, or cardiovascular impairment
6
Q
Interleukins-
Adverse effects
A
- Lethargy
- Myalgia
- Arthralgia
- Fever
- Resp. difficulties
- depression with suicidal ideation
