Disease-Modifying Antirheumatic Drugs Flashcards
1
Q
DMARDS
A
- Treat arthritis and aggressively affect the process of inflammation
- they alter the course of the inflammatory process
2
Q
2 types of DMARDs-
A
-Tumor Necrosis Factor TNF Often the 1st class of meds used with progressing arthritis
-Other DMARDs
3
Q
TNF-
MOA
A
TNF blockers decrease local effects on TNF, a locally released cytokine that can cause death of tumor cells and stimulate a wide range of proinflammatory activities.
4
Q
TNF-
Indications
A
- RA
- Polyarticular Juvenile arthritis
- Psoriatic arthritis
- Plaque psoriasis
- Ankylosing spondylitis
- Also used in Crohn Dz and ulcerative colitis
5
Q
TNF-
Names
A
- Adalimumab
- Etanercept (P)
- Infliximab
6
Q
TNF-
Contraindications
A
- Acute infection
- Cancer
- Sepsis
- TB
- Hepatitis
- Myelosuppression or demyelinating d/o’s
7
Q
TNF-
Cautions
A
- Pregnancy/lactation
- Hepatic and renal d/o’s
8
Q
TNF-
Adverse effects
A
-BLACK BOX WARNING for risks of serious to fatal infections and the development of lymphomas and other cancers
9
Q
TNF-
Drug-Drug
A
- Immune suppressant drugs
- Live vaccines
10
Q
TNF-
Nursing considerations,
Assessing
A
- Allergy
- Signs of infection
- Arrange for required cancer screenings
- Monitor ROM
- Monitor labs
11
Q
TNF-
Nursing considerations,
Implementation
A
- Teach pt proper preparation, admin, and SUBQ injec
- Monitor for immune suppression
- Routine cancer screenings
12
Q
Antiarthritis Agents-
A
-Gold Compounds
-DMARDs (2)
TNF, other DMARD
