Antiarthritis Agents Flashcards
1
Q
Gold Compounds-
MOA
A
Gold is taken up by macrophages, which then inhibit phagocytosis = decreased tissue destruction
2
Q
Gold compounds-
Indication
A
Used to prevent and suppress arthritis in selected patients with RA
Used with patients that are unresponsive to conventional therapy and can be very toxic
3
Q
Gold compound-
also called….
A
Chrysotherapy
-patients respond to treatment with gold salts
4
Q
Gold compound-
Contraindications
A
- Allergy to gold or metals
- Severe diabetes
- CHF
- Renal or hepatic impairment
- HTN
- Blood dyscrasias
- Recent radiation therapy
- Pregnancy and Lactation
5
Q
Gold compounds-
Adverse Effects
A
- Stomatitis
- Glossitis
- Gingivitis
- Bone marrow depression
- Interstitial pneumonitis
- Anaphylactic shock
6
Q
Gold compounds-
Drug-Drug
A
- Penicillamine
- Antimalarials
- Cytotoxic drugs
- Immunosuppressive agents
increased risk for toxicity
7
Q
Gold compounds-
Name
A
Auranofin
8
Q
Antiarthritis Agents
A
-Gold Compounds
-DMARDs (2),
TNF, other DMARDs
