Anti-inflammatory, Antiarthritis and related agents Flashcards
Different types of drugs
Corticosteroids
Antihistamines
Immune-modulating agents
OTC anti-inflammatory
Salicylates-
Indications
- Block the inflammation response
- Antipyretic (fever blocking)
- Analgesic (pain blocking)
Treatment of RA and Osteoarthritis
Salicylates-
Drugs names
Aspirin (P)- treats inflammation (and also reduction of risk of transient ischemic attack, stroke, and MI)
Mesalamine- treats inflammation of large intestine
Salicylates-
MOA
Inhibit the synthesis of prostaglandin
an important mediator of the inflamm. reaction
Salicylates-
Contraindications
- Allergy
- Bleeding abnormalities
- Impaired renal function
Salicylates-
Adverse effects
- Clotting effects
- GI effects
Salicylates-
Drug-Drug
Many other drugs- look them up, interferes with absorption
Salicylates-
Nursing considerations
Assessment
-Assess for allergy, renal dz, bleeding d/o’s, chickenpox or influenza (in children), pregnancy/lactation.
Salicylates-
Nursing considerations
Implementation
- Admin with food if GI upset. Provide small, frequent meals
- Check all drugs being taken for salicylate ingredients
Nonsteroidal Anti-inflammatory Drugs
(NSAIDs)
MOA
Blocks COX-1 and COX-2 enzymes
NSAIDs-
Indications
- Anti-inflammatory
- Analgesic
- Antipyretic
NSAIDS-
Contraindications
- Pregnancy/Lactation
- Allergy, increased sensitivity
- CV dysfunction
- GI bleed
- Peptic Ulcer
NSAIDs-
Caution
-Renal and hepatic dysfunction (alters excretion and metabolism)
Common NSAIDs-
Propionic Acids-
Ibuprofen (P)
Naproxen
Acetic Acids-
Indomethacin
Ketolorac
Osicam Derivatives-
Meloxicam
Cyclooxygenase- 2 inhibitors-
Celecoxib
NSAIDs-
Adverse Effects
-Nausea
-Dysuria
-GI pain
-Constipation
-Flatulence
-GI bleeding- STOP TAKING!!
-Somnolence
-HA/Dizziness
-Fatigue
-pH inhibition
HTN
-Bone marrow depression (chronic use)
-Rash, mouth sores
