Colony-stimulating factors Flashcards
1
Q
Colony-stimulating factors
Indications
A
Increase the production of neutrophils in the bone marrow with little effect on other hematopoietic cells
2
Q
Colony-stimulating factors
MOA
A
Can be used to reduce the incidence of infection with bone marrow suppression, decrease neutropenia associated with bone marrow transplants and chemotherapy and helps in treatment of blood related cancers
3
Q
Colony-stimulating factors
Name
A
Filgrastim (P)
4
Q
Colony-stimulating factors
Adverse Effects-
A
- HA
- GI related
- Fatigue
- Alopecia
- dermatitis
- diarrhea
- stomatitis
- anorexia
- bone pain
- cough
- generalized pain
5
Q
Colony-stimulating factors
Contraindications
A
- Any allergy to any component of the drug
- renal or hepatic dz
- preg/lact
- radiation/chemotherapy
6
Q
Colony-stimulating factors
Drug-Drug
A
increase in the myeloproliferative effects of sargramostim when combined with lithium or corticosteroids
7
Q
Colony-stimulating factors
Assessing-
A
- Assess for contraindications and allergies
- Hx of renal/liver/cardiac dz
- Obtain a baseline EKG
- Assess skin lesions, weight, monitor temp, heart rate, rhythm, BP, orientation and reflexes. yu
8
Q
Colony-stimulating factor
Dx
A
- Acute pain r/t CNS, GI and flu like sx
- Imbalanced nutrition: Less than body requirements
- Anxiety
9
Q
Colony-stimulating factors
Implementation
A
- Lab tests before and during
- instruct for proper admin, oral or injections
- Advise female pts to use barrier contraceptives
