Glucocorticoids

Question 1

Glucocorticoids

MOA-

Answer 1

• Enter target cells and bind to cytoplasmic receptors
• Initiate many complex reactions responsible for anti-inflammatory and immunosuppressive effects
• Hydrocortisone, cortisone, and prednisone have some mineralocorticoid activity

Question 2

Glucocorticoids

Indications-

Answer 2

• Short term treatment of many inflammatory disorders
• To relive discomfort
• To give the body a chance to heal from the effects of inflammation

Question 3

Glucocorticoids

Contraindications-

Answer 3

• Allergy
• Acute infection
• Lactation

Question 4

Glucocorticoids

Caution-

Answer 4

• Diabetes

- Acute peptic ulcer

Question 5

Glucocorticoids

Adverse effects-

Answer 5

• HA
• Insomnia
• Psychosis
• GI upset
• HF
• Fluid retention
• Increased glucose
• Osteoporosis
• Frail skin
• Growth retardation (children)
• Diabetes
• Cushing syndrome
• Impaired wound healing
• Aggravating or masking of infections

Question 6

Glucocorticoids

Drug-Drug

Answer 6

• Increase this drug if taking Erythromycin, ketoconazole, or troleandomycin
• Decrease in drug when given with salicylates, barbiturates, phenytoin or rifampin