Interleukin Functions

Question 1

IL-1

Answer 1

Causes fever, acute inflammation
Activates endothelium to express adhesion molecules
Induces cytokine secretion to recruit WBC
Also known as osteoclast activating factor

Question 2

IL-6

Answer 2

Causes fever and stimulates production of acute phase proteins

Question 3

IL-8

Answer 3

Major chemotactic factor for neutrophils

Question 4

IL-12

Answer 4

Induces differentiation of T cells into Th1 cells

Activates NK cells

Question 5

TNF alpha

Answer 5

Activates endotheium
Causes WBC recruitment and vacular leak
(Cachexia in malignancy and maintains granulomas in TB)

Question 6

IL-2

Answer 6

Stimulates growth of helper, cytotoxic, and reg T cells

Question 7

IL-3

Answer 7

Supports growth and differentiation of bone marrow cells

Functions like GM-CSF

Question 8

IFN gamma

Answer 8

Secreted by NK cells and T cells in response to antigen or IL-12 from macrophages
Stimulates macrophages to kill phagocytosed pathogens
Inhibits differentiation of Th2 cells

Question 9

IL-4

Answer 9

Induced differentiation of T cells into Th helper 2 cells
Promotes growth of B cells 
Enhances class switching to IgE and IgG

Question 10

IL-5

Answer 10

Promotes growth and differentiation of B cells
Enhances class switching to IgA
Stimulates the growth and differentiation of eosinophils

Question 11

IL-10

Answer 11

Attenuates inflammatory response
Decreases expression of MHC class II and Th1 cytokines
Inhibits activated macrophages and dendritic cells
Also secreted by regulatory T cells