Immune System Disorders

Question 1

Some with early complement deficiency (C1-C4) has an increase risk of what?

Answer 1

Severe, recurrent pyogenic sinus and respiratory tract infections and a increase risk of SLE

Question 2

Terminal complement deficiency (C5-C9) has susceptibility to what bacteria?

Answer 2

Neisseiria

Question 3

C1 esterase inhibitor deficiency is caused by what?

Answer 3

Hereditary angioedema due to unregulated activation of kallikrein leading to increase in bradykinin. Characterized by a decrease in C4 levels

Question 4

What drug is CI in those with C1 esterase inhibitor deficiency?

Answer 4

ACE Inhibitors

Question 5

Paroxysmal Nocturnal Hemoglobinuria

Answer 5

Defect in the PIGA gene preventing the formation of anchors for complement inhibitors such as decay accelerating factors and membrane inhibitors of reactive lysis
Cause complement mediated RBC lysis