Immunosuppressants

Question 1

MoA Cyclosporine

Answer 1

Calcineurin inhibitor that binds cyclophilin. blocks T cell activation by preventing IL-2 transcription

Question 2

Cyclosporin main ADR (3)

Answer 2

NEPHROTOXIC
Hirstism
Gingival hyperplasia

Question 3

Tacrolimus MoA

Answer 3

Calcineurin inhibitor that binds FK506 binding protein. Blocks T cell activation by preventing transcription of Il-2

Question 4

Tacrolimus main ADR (3)

Answer 4

NEPHROTOXIC
Increase risk Diabetes
Increase risk neurotoxicity

Question 5

Sirolimus MoA

Answer 5

mTOR inhibitor that binds FKBP

Blocks T cell activation by preventing transcription of IL-2

Question 6

Sirolimus ADR (2)

Answer 6

Pancytopenia

Insulin Resistance

Question 7

Basiliximab MoA

Answer 7

Monoclonal Ab that block IL-2R

Question 8

Azathioprine MoA

Answer 8

Antimetabolite precursor of 6-Mercaptopurine that inhibits lymphocyte proliferation by blocking nucleotide synthesis

Question 9

What can increase the toxicity of Azathioprine?

Answer 9

Allopurinol

Question 10

Mycophenolate MoA

Answer 10

Reversibly inhibits IMP dehydrogenase, preventing purine synthesis of B and T cells

Question 11

Mofetil MoA

Answer 11

Reversibly inhibits IMP dehydrogenase, preventing purine synthesis of B and T cells

Question 12

Which drug is assc with invasive CMV infection?

Answer 12

Mycophenolate