Integument Physiology II Flashcards

1
Q

Thickness of skin layers (from thickest to thinnest).

A

Hypodermis, dermis, epidermis

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1
Q

Pneumonic for layers of epidermis?

A

Come Get Sun Burnt

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2
Q

List four layers of epidermis? Innermost to outermost?

A

Stratum basale, stratum spinosum, stratum granulosum, stratum corneum

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3
Q

How many layers in stratum basale? Types of cells? Most common type of cell? Movement?

A

Single layer; columnar to cubiodal cells; keratinocytes; upwards to replenish epidermis

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3
Q

Main functions of stratum basale?

A
  1. Anchor epidermis to dermis
  2. Proliferative and reparative (stem cell function)
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4
Q

What is another name for the stratum spinosum?

A

Prickle cell layer

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5
Q

Composition of SS?

A

Daughter cells of SB

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6
Q

How many layers in SS?

A

1-2 layers thick

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6
Q

Why is the SS also called prickle cell layer?

A

keratinocytes are also connected by intercellular bridges or prickles

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7
Q

What does the stratum spinosum synthesize?

A

lamellar granules (glycoproteins, glycolipids, phospholipids)

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8
Q

Function of lamellar granules?

A

barrier function

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9
Q

Composition of SG?

A

SS and SS daughter cells

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10
Q

Three substances in SG?

A

Pilofilaggrin, keratin filaments, loricin

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10
Q

SG thickness in haired vs non haired regions?

A

1-2 cells thick; 4-8 cells thick

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11
Q

Cell shape and color of SG?

A

Flattened and basophilic (blue)

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11
Q

What are filaggrin degradation products responsible for?

A

SC hydration and UV light barrier

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12
Q

SG nuclei size and substance in cytoplasm?

A

small, keratohyalin granules

13
Q

Keratinocytes are constantly being ____ in SC.

A

shed

14
Q

Cell shape of corneocytes, nuclei composition, and type of cell in SC?

A

flattened, anuclear cells, eosinophilic

15
Q

Where are corneocytes located in the SC?

A

multilayered zone suspended in extracellular lipid matrix

16
Q

How often do dogs replace their epidermal layer?

A

Every 20-25 days

16
Q

What do corneocytes contain?

A

Humectants/sunscreens

17
Q

What are adnexa?

A

Structures of the skin

17
Q

What maintains epidermal thickness?

A

Proliferation of basal cells

18
Q

What is the function of the cornified envelope?

A

Structural support to the cell and resists invasion

19
Q

In hairless areas, hair follicles include ___________ __________.

A

mucocutaneous junctions

20
Q

Describe simple vs compound hair follicles. Example of species of each.

A

Simple: single hair from one orifice Ex. Pig, horse
Compound: Multiple hairs from one orifice Ex. dogs, cats, sheep

21
Q

Describe primary vs. secondary hair shafts.

A

Larger “guard hairs”
Smaller “undercoat”

22
Q

What are tactile hairs, what are they surrounded by and function?

A

Large, simple hair
Surrounded by blood sinus
Sensory

22
Q

Describe the anatomy of a follicle (3 parts)

A

Infundibulum: Superficial part
Isthmus: middle part, arrector pili m. attachment
Inferior: deepest, produces shaft (anagen), holds during rest (telogen)

23
Q

What do sebaceous glands produce?

A

sebum- oily secretion

24
Q

What do sebaceous glands combine with to form?

A

Combines with sweat to create hydration and chemical barrier

25
Q

Where do sweat glands open up into?

A

superficial portion of hair follicle

25
Q

What are sweat glands lined with?

A

Epithelium and contractile myoepithelial cells

25
Q

Where do sebaceous glands open into on hair follicles? Some open up where?

A

deep portion of infundibulum; open on surface of the skin

26
Q

Difference between apocrine and eccrine glands?

A

Apocrine: on the hair follicle
Eccrine: NOT on the hair follicle, open on the epidermal surface, tubular

27
Q

What are the four stages of the hair cycle?

A
  1. Anagen
  2. Catagen
  3. Telogen
  4. Exogen
28
Q

Provide one word association with each of the hair cycles. (Anagen, catagen, telogen, exogen)

A

Anagen: Growth
Catagen: Regression
Telogen: Resting
Exogen: Shedding

29
Q

Where does cyclic activity primarily occur?

A

Below the insertion of arrector pili m. of hair follicle

30
Q

What does the duration of phase depend on?

A

age
region
breed
sex
physio/path factors

31
Q

What is the hair cycle controlled by?

A

Photoperiod
Ambient
Temp
Nutrition
Hormones
Overall Health
Genetics