integration Flashcards
How in energy provided
by fat and CHO
how much eneergy is provided by fat at rest
50%
how much body mass is skeletal muscle
40-50%
how much oxygen consumption os skeletal muscle responsible for
20-30%
how much insulin-mediated glucose disposal in mediated by skeletal muscle
75%
what is Randals cycle
everything about metabolism is dictated by fat
what is the effect of having access fat according ot the randall cycle
excess fat = greater production of acetyl co-A
more citrate produced - regulated aspets of metabolism, inhibits PFK and therfpre glycolysis
key regulator of GLUT 4
PI3K
insulin
effect of malonyl coA
inhibits CPT1
tth fat oxidation could use this enzyme when problems wih
effect of increasing FFA availiabilty on on CHO
inhibits CHO oxidation at multiple sites
effect on increasing glucose availabilty on Fat oxidation
inhibits fat oxidation at CPT1
effect of carnitine supplementation on fat and CHO oxidation
little impact on fat and CHO metabolism and exercise performance
reductioin in lactate at high intensity
what is insulin resistane
the reduced responsivness of skeletal muscle glucose uptake to normal circulation levels on insulin
effect of insulin resistance
impaired ability of insulin to
- stimulate glucose oxidation
- to stimulate microvascular perfusion
- to stimulate amino aid uptake into muscle cells
- to inhibit muscle protein breakdown
