Insomnia Drugs

Question 1

What benzodiazepine drug can be used to treat insomnia? What are the diadvantages of using benzos for insomnia???

Answer 1

You could use tamazepam. The benzos allows you to get to sleep faster but also decrease REM sleep.

Question 2

Instead of benzos, what drugs are used to treat insomnia?

Answer 2

Instead of benzos, you can use non-benzodiazepin GABA receptor agonist.

Question 3

What are the names of three non-benzodiazepine GABA receptor agonists used for insomnia?

Answer 3

Zaleplon, zolpidem, and eszopiclone.These are better because they do not affect REM sleep.

Question 4

What are the two mai benefits of using NBRA drugs to treat insomnia?

Answer 4

1) they do not inhibit REM and 2) they have a low dependence/abuse potential associated with them.

Question 5

How are the NBRAs metabolized?

Answer 5

p450 system (exclusively)

Question 6

Ramelteon

Answer 6

Melantonin (MT1 and MT2) reeptor agonists. SHortens sleep latency but does not prolong maintenance.

Question 7

How is Ramelteonn metabolized? What are the contraindications for this drug?

Answer 7

Metabolized by CYP1A2. Do not give with FLUVOXAMINE (inhibits CYP12A).