Alzheimer's DIsease Treatment

Question 1

Donepezil (aricept)

Answer 1

Block Acetylcholinesterase in brain increases [ACh]. Only relieves symptoms for 6 months then regression seen.

Question 2

Rivastigmine

Answer 2

ACHE-I and Butryl-cholinesterase inhibitor (block the thing breaking down the acetylcholine, this will increase levels)

Question 3

Galantamine

Answer 3

CHE-I

Question 4

Memantine (two N’s and two M’s)

Answer 4

NMDA receptor antagonist.. decreases plasticity of neurons. Gven in patients in advanced stage of disease.

Question 5

What are the major toxicities involved with the aforementioned drugs used to treat AD?

Answer 5

Nausea and vomiting.