Barbituates and Alcohols

Question 1

What do you need to know about barbituate withdrawal…

Answer 1

The faster acting, more potent barbituates will have a more severe (worse symptoms and more intens withdrawal symptoms) for a shorter period of time, when compared to a long acting barbituate (will have a less intense but longer withdrawal period).

Question 2

What is the drug you use when someone has over dosed on alcohol or ethylene glycol, or methanol

Answer 2

Fomeprizole

Question 3

What are the three most used barbituates??

Answer 3

Thiopental, Secobarbital, Phenobarbital

Question 4

How do Barituates cause CNS depression?

Answer 4

Bind to GABA-A receptors and increase GABA effect… the channel stays open for longer

Question 5

What drugdo you use for barbituate overdose??

Answer 5

Flumazenil

Question 6

Thiopental

Answer 6

Used for brief anesthesia, ultrashort duration

Question 7

Secobarbital

Answer 7

Used for preanesthetic sedation, and as a hypnotic (sleep aid); Intermediate duration

Question 8

Phenobarbital

Answer 8

Long acting; daytime sedation and anticonvulsant (seizures).

Question 9

What happens when you take barbituates at a low dose, middle dose, and then high dose??

Answer 9

At a low dose barbituates are sedative like, create euphoria, and loss of inhibition. At MEDIUM DOSES: barbituate can cause pleasureable intoxication, decreased activity and drowsiness. At HIGH Doses: severe intoxication, intense emotions, and sleep (CV, RESP depression, non-reactive pupils and hypothermia).