Inorg Chem Lab ORS Flashcards
ORS
Oral rehydration solution
Best method for combatting dehydration
50mL/kg mild diarrhea
100mL/kg moderate diarrhea
Every 4h
10mL/kg every diarrheal stool, after 4h reassess the patient
5mL/kg every 5mins for vomiting increasing gradually as tolerated
Potassium in ors
Promote a feeling of well being, stimulate appetite and activity of the patient
Potassium unlike sodium is absorbed passively
Loss of potassium results in muscular weakness, lethargy and anorexia
Bicarbonate in ors
To correct the electrolyte imbalance
metabolic acidosis
Precipitated sulfur
equation
3 CaO + 3 H2O -> 3 Ca (OH)2
3 Ca(OH)2 + 12S -> 2 CaS5 +CaS2O5+3H2O
2CaS5 + 4HCl -> 8S + 2 CaCl2 + 2 H2S
Precipitated Sulfur
Properties
Color- pale yellow
Odor- odorless
Form- very fine amorphous powder
Litmus paper result- B>R, R>B
Neither acidic nor basic (neutral)
Precipitated Sulfur
Test of purity
R>B, B>R
+ K2C2O4 -no ppt
+AgNO3 -no ppt
Dissolves readily
Absence sulfur, Ca2+, Cl-
Neutral
Slaking
Addition of water to lime CaO with the liberation of heat
The solution is kept alkaline because flowers of sulfur contains amount of arsenic pentasulfide digested with Ca(OH)2, calcium sulfuarsenite which is soluble in alkaline liquid
If made acidic, it will contaminate the precipitated sulfur
Kind of preparation
Liquid mixture because particles since it is lighter and easily suspended
Lime
CaO
Calcium oxide
Lime water
Ca(OH)2 sol’n
Calcium hydroxide soln
Slaked lime
Ca(OH)2
Calcium hydroxide
Limestone
CaCO3
Calcium carbonate
Milk of lime
Ca(OH)2 susp
Calcium hydroxide susp
Other forms of sulfur
Official prep
Sublime sulfur
Wash sulfur
Other forms of sulfur
Allotropic forms
Chrystalline
Rhombic or octahedral sulfur
Monoclinic or prismatic sulfur
Plastic
Uses of sulfur
Scabicide
Cathartic
Aid in fumigation
Keratolytic (fungicidal action)
Treatment for seborrhea and burns
Prepration for Boric Acid
Equation
B4O7.10H2O+2HCl > 4H3BO3+2NaCl+5H2O
Boric acid properties
Colorless
Odorless
Sour
Boric acid
Test for identity
Litmus: R>R, B>R acidic
Turmeric paper: brownish black
+NH4OH: greenish black
Methanol sulfuric acid test: green border flame
Acidic
Boric acid
Test for impurities
Result: clear soln
Conclusion: absence of water insoluble subs
+AgNO3: no ppt absence of Cl ions
Boric acid therapeutic uses
Eyewash (collyra)
Bacteriostatic agent
Buffer component
Boric acid forms
1- Chrystalline dissolves thoroughly
2- Powder tend to float on top of aqueous solvent
Magnesium carbonate
properties
White amorphous powder
Slight earthly taste
Relative bulk: bulky powder
Magnesium carbonate
Test for identity
+CO3 2-
Effervescence was produced
+Mg2+
White chrystalline ppt
Reagent
KH2SbO4 > NaH2SbO4> white ppt >Na+
BaCl2> BaSO4> white ppt> SO4 2-
Factors to determine the variety of MgCO3
Volume of water added
Temp of water added
Rapid filtration of voluminous substances
Buchner funnel
The bubbling of a solution due to the escape of gas
As in carbonated drink
Effervescence
Therapeutic uses of MgCO3
Antacid
Laxative
Magnesium oxide
Equation
(MgCO3)4.Mg(OH)2.5H2O > 5MgO+4CO2(g)+6H2O
Magnesium oxide MgO
Properties
White powder
Odorless
Tasteless
Light variety-bulkier
MgO test for identity
Litmus: R>B acidic
Mg(OH)2+2HCl>MgCl2+2H2O
Formula: MgNH4PO4
Color & nature: white
Process of heating without melting or fusion
Calcination
MgO
Test for the presence of carbonate
Add acetic acid
No effervescence indicates complete inversion of carbonate and oxides
MgO therapeutic uses
Laxative
Diuretic
Antacid
Potassium acetate
CH3CO2K
Equation
CH3COOH+KHCO3>CH3COOK+CO2+H2O
Potassium acetate
CH3CO2K
Properties
White amorphous powder
Faint acidous odor
Slightly alkaline taste
CH3CO2K
Test for identity
+K +
K2NaCo(NO2)6
Yellow ppt
+CH3COO
Gas with vinegar odor
+K & C
Residue of K2CO3
Used to increase temp over 100deg C and not to exceed 140deg C during evaporation of
Sand bath
A form of treatment that chemically decomposes organic materials by heat in the absence of oxygen
Pyrolysis
Therapeutic uses of KCH3COO
Potassium salt of acetic acid
Diuretic
Antacid
Potassium sodium tartrate
Properties
White chrystalline powder with colorless rhombic prism
Odorless
Saline cooling taste
Potassium sodium tartrate
KNaC4H4O6.4H2O
Potassium sodium tartrate
Tollens test: silver mirror
+CH3COOH
White chrystalline ppt
KHC4H4O6
Potassium sodium tartrate
Effervescence gives off CO2
Synonyms of KNaC4H4O6
Rochelle salt
Seignette salt
Class of salt: double salt
Implication on pyrolysis
No ample supply of O2
Insufficient heating
Black carbon particlea remain
KNaC4H4O6 therapeutic uses
Cathartic (component of seidlitz powder)
Mild laxative
Potent hydragogue (evacuation of watery feces)
When the certain solid substances when exposed absorb water enough to form solutions
Deliquescence
When some substance are exposed to air, they lose water to the atmosphere, thereby reducing in weight
Efflorescence
When the substance absorb water from air but not enough to form solutions
Hygroscopic
Fehling’s soln-alkaline CuC4H4O6
Test the presence of aldehydes
Property of tartrate ion
Chelate complex atom
Iodine tincture category
Topical tincture
Iodine tincture synonyms
Tincture of iodine
Tinctura lodi
Solutio lodi
Iodine tincture
Description of final product
The tincture has a reddish brown color which produce stain on the skin
Iodine tincture uses
1- Local anti infective agent applied topically to the skin
2- Germicide
3- Fungicide
Latin macerare (to soak)
Comminuted drug is permitted to siak in the menstruum
Agitated repeatedly over a period of time 2-14 days
Maceration
Latin per (through) colare (to atrain)
Comminuted drug is extracted by the slow passage of a suitable solvent through a column of the drug
Drawn by the force of gravity as well as the weight of column of the liquid
Percolation
On a small scale
Use glass percolators
Suited to the more complete extraction of drugs with minimal expenditure of menstruum
Cylindrical percolator
Glycyrrhiza fluidextract
Licorice root
Flavoring agent
Eriodictyon fluidextract
Yerba santa
Cathartic
Cascara sagrada fluidextract
Rhamnus purshiana fluidextract
Aromatic cascara sagrada fluid extract
Senna fluidextract
Fluidextratum sennae
Concentrated preparations of veg or animal drugs obtained by the removal of the active constituents of the reapective drugs with suitable solvent
Extracts
Add solvent to the drug, either macerate/percolate
Obtain through evaporation
2-6 times more potent than the crude drug
Syrupy
Syrupy/semiliquid
20mL of solvent system is remained
Removing all or most of the menstruum
Plastic consistency, nearly all solvent(menstruum) has evaporated
Preffered in compounding dosage form:
Ointment/paste/pliable material facilitates compounding
Pilular / plastic consistency
Dry extract by removing all menstruum
Veg drug material which are starchy
Preffered compounding of: powders, capsules, tablets
Powdered extract
Nasal decongestant solutions
Treat rhinitis of the common cold, for sinusitis
Potassium oxalate
+K2C2O4
AgNO3
Silver nitrate
Calcium hydroxide
Ca(OH)2
Ammonium hydroxide
NH4OH
HCl is used instead of Sulfuric acid because
HCl is a soluble acid hence residual traces of HCl will remain in crystal surfaces while h2so4 is non soluble acid and is less easily remoed
Test of washings for chloride ions
Add of agno3
No ppt indicates the absence of Cl ions
Cold water is used for washing the crystals
Because it is less soluble in cold water
Official solution before opthalmic prep
Since the solution might crystallized and will be irritating to the eyes
Magnesium carbonate
Equation
Light variety
Heavy variety
CO3 2-
Carbonate ion
CuC4H4O6
Copper (II) Tartrate