Innate to Adaptive Immunity Flashcards
What are the things innate immunity recognizes?
- PAMPs (pathogen-associated molecular patterns)
- DAMPs (damage-associated molecular patterns/signals)
- ABSENCE of certain normal cell surface molecules
Describe the relationship between PRR and TLR and what TLRs do.
PRR (pattern-recognition receptors) are on the surface or inner membrane of cells. A specific class of PRRs is the TLR (Toll like receptors), which recognize foreign molecular structures (ie double stranded RNA).
Activation of TLR often leads to nF-KB activation, which is the mother of all inflammatory transcription factors.
What is the “bridge” between innate and adaptive immunity?
Dendritic cells (antigen presenting cells)
True or False: Adaptive immunity response cannot be triggered in the periphery.
TRUE. It is activated in lymphatic tissues.
Lymphocytes main job is ___________
Recognition of foreign objects
Phagocytes main job is ___________
Eating foreign objects
What is the antigen region called that binds to immune receptors on lymphocytes?
Antigenic Determinant or Epitope
10-20 Amino acids long usually
True or false: Antibodys or immune receptors are made to recognize pathogens after infection.
FALSE:
Antibodies are PREDICTIVE not REACTIVE
What happens when a lymphocyte binds an epitope?
Activation of Proliferation of that specific lymphocyte to mount a defense response.
T-cells work closely with which kind of cell?
Antigen Presenting (Dendritic) cells.
When T-cell recognizes an APC, then the T cell proliferates and sends T-cells to find the pathogen in the body.
What is the main function of a B-cell?
Arrange for the phagocytosis and destruction of foreign materials.
B-cells secrete Antibodies.
Give an example of a type I immunopathology, hypersensitivity:
Bee sting allergy.
What is Type II immunopathology
Auto immune disease
