Hematopoiesis

Question 1

G-CSF growth factor stimulates_________

Answer 1

Granulocyte-colony stimulating factor

Growth of Neutrophils, basophils and eosinophils.

All the granulocytes

Question 2

What does EPO do?

Answer 2

Activates production of RBC

Question 3

The central pallor of a RBC is what fraction of its diameter?

What is the diameter?

Answer 3

1/3

6-8 micron

Question 4

What is the basic lineage of an RBC?

Answer 4

Pronormoblast
Normoblast
Reticulocyte
RBC

Question 5

What is responsible for production of megakaryocytes and platelets?

Answer 5

Thrombopoietin.

Think thrombocytes

Question 6

How do neutrophils kill?

Answer 6

Phagocytosis

Degranulation

Question 7

What are the life spans of RBC, Platelets and Neutrophils?

Answer 7

1. 120 Days
2. 7 days
3. 7 hours (half life)

Question 8

What is the difference between an HSC and a CFU?

Answer 8

Hematopoetic Stem Cell vs Colony Forming Unit

HSC- ALL types of blood
CFU- lymphoid or non lymphoid blood cells (eg CFU-L= lymphoid cells)

Question 9

What promotes the growth of the following:
RBCs
Thrombocytes
Granulocytes
Monocytes
Eosinophils
Basophils

Answer 9

RBCs  - EPO
Thrombocytes - TPO
Granulocytes - G-CSF
Monocytes -    M-CSF
Eosinophils-    IL-5
Basophils -      IL-3

Question 10

What is the mnemonic for Erythrocyte maturation?

Answer 10

Pro- no- poly- ortho

pronormoblast → basophilic normoblast → polychromatophilic normoblast →
orthochromatic normoblast → reticulocyte → erythrocyte.