Innate Immune System Flashcards
3 Layers of Pathogen Response
Prevent Pathogen Entry
Recognize non self and modified self
Respond by Eliminating Pathogen
Disease
Condition or Illness that prevents body and mind from functioning properly
Host Microbiome Symbiosis
Host provides environment and nutrients
Microbes make nutrients useable
Mucosal Surfaces Microbes Reside
Urogenital Tract
Respiratory Tract
GI Tract
If tolerance for microbes doesn’t develop at a young age
Disease Develops
Immunity
Protection provided by immune system to protect against microbial infection provided by humoral proteins and cells
If innate and acquired response is inadequate response is
Ineffective
Excessive innate and acquired response can cause
Inflammatory Disease
Tumor Cells
Atopic Disease by sensitization to environmental antigens
Autoimmune disease by sensitization to self antigens
Innate Immune Response
- Neural cells become activated by binding of cytokines and neuropeptides which alerts CNS to danger
- Danger signals perceived in brain
- Responds with neural (SAM & PNS) and endocrine (HPA) signals to regulate effective immune response
Hypothalamus cytokines (IL-1, IL-6 and TNFa) cause what response
Fever
Which hypothalamic cytokine is responsible for inducing sickness behaviour (sleepiness, anorexia)
IL-1
In Muscles cytokines are used for protein catabolism, protein is used for host and tissue defence proteins which are also known as _
Hepatic APPs
Flaws of Innate Immune System
Limited Specificity
No immunological memory
Might not be strong enough response
Can result in SIRS
SIRS can cause Sepsis and Death
SIRS affected individuals immunocompromised and at risk for secondary infections
Benefits of Innate Immune Response
Highly effective at eliminating pathogens
Host inflammatory response localized to infection
Cytokine secretion is caused by _ _ binding to _
Danger Signals, PRRs
2 Types of Danger Signals
Alarmins, MAMPS
