Epigenetics

Question 1

Variation in gene activity is controlled by _ and _

Answer 1

Genetics, Epigenetics

Question 2

Genetic Variation like SNP are _ and _

Answer 2

Permenant
Inherited

Question 3

Epigentic Variation

Answer 3

Adaptive
Inherited
Phenotypic Variation

Question 4

Epigenetic Modification

Answer 4

DNA Methylation
Histone Protein Modification
Non coding mRNAs

Question 5

DNA methylation cause

Answer 5

transcriptional silencing

Question 6

Histone Protein Modification Modes

Answer 6

Methylation - silencing
Acetylation - enhances
Phosphorylation

Question 7

Non coding mRNA

Answer 7

miRNA - mRNA degradation, silencing
ncRNA

Question 8

Promoter region GR of Nerve Growth Factor induced protein A can be methylated = negative HPA feedback
GR decrease with miRNA-18 and -124a = less

Answer 8

IFNy

Question 9

USP8 Gene Polymorphism

Answer 9

Associated with Increase ACTH
Risk Factor for Cushings

Question 10

ARMC5 Gene Mutation

Answer 10

Tumor Suppressor Gene
Associated with adrenal enlargement
Risk Factor for Cushings

Question 11

Cushings caused by tumour on _ _ which causes overproduction of _ and increases _ so that they don’t _ at night

Answer 11

Anterior Pituitary
ACTH
GCs
Decrease

Question 12

Addisons is an autoimmune disease that attacks _ cells. Adrenal cortex size . Leads to underproduction of , and accumulation of _,, . Cause _ in MHC, CTLA4, CYP, 3B-HSD2

Answer 12

adrenal
decreases
GC
POMC, ACTH, MSH
polymorphism