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Anesthesia&Surgery > Injectable Anesthetics > Flashcards

Injectable Anesthetics Flashcards

0
Q

The Barbiturate drugs

A

Thiopental
Pentobarbital
Phenobarbital

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1
Q

What are the 3 classes of injectable anesthetics?

A

Barbiturates
Non-Barbiturate/Hypnotics
Dissociatives

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2
Q

The Non-Barbiturate drugs

A

Propofol

Etomidate

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3
Q

The Dissociative drugs

A

Ketamine

Tiletamine

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4
Q

Can injectable anesthetics produce unconsciousness when given alone?

A

Yes

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5
Q

Can injectable anesthesia provide analgesia or muscle relaxation?

A

No

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6
Q

Barbiturates are derivatives of this acid

A

Barbituric acid

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7
Q

This class of injectable anesthetic is controlled

A

Barbiturates

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8
Q

This class of injectable anesthetic does not have a reversal agent

A

Barbiturates

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9
Q

The classes of Barbiturates are based on this

A

Duration of action

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10
Q

Drug with Ultra short Duration of action

A

Thiopental

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11
Q

Drug with short Duration of action

A

Pentobarbital

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12
Q

Drug with long-acting Duration of action

A

Phenobarbital

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13
Q

Which barbiturates are no longer used as anesthetics?

A

Most intermediate and long acting

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14
Q

What are the 2 sub classes of Barbiturates based on chemical structure?

A

Oxybarbiturates

Thiobarbiturates

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15
Q

Which drugs are Oxybarbiturates?

A

Phenobarbital
Pentobarbital
Methohexital

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16
Q

Which drugs are Thibarbiturates

A

Thiopental

Thiamylal

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17
Q

Which is the only barbiturate used in sx?

A

Thiopental

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18
Q

Which barbiturate is used as an anticonvulsant?

A

Phenobarbital

19
Q

This class mimics GABA

A

Barbiturates

20
Q

This class depresses impulses to cerebral cortex

A

Barbiturates

21
Q

Factors that affect potency, onset, and duration of action of barbiturates

A

Ionization
Protein binding
Lipid solubility

22
Q

Non-polar form of barbiturate drug passes through this

A

Cell membrane

23
Q

Acidosis increases this

A

Non-ionized form of the drug

Drug amounts to the brain

24
Q

What should be done to the dose of a barbiturate if given to an acidotic animal?

A

Lower dose

25
Q

Protein binding drugs travel in this

A

In blood bound to a protein

26
Q

An unbound drug can enter here

A

Brain

27
Q

This results in more free drug

A

Hypoproteinemia

28
Q

If hypoproteinemia occurs, normal drug (barbiturate) dose may actually produce this

A

Prolonged unconsciousness or death

29
Q

What is lipid solubility?

A

The tendency of the drug to dissolve in fats, oils, and lipids

30
Q

Lipid solubility affects this

A

The ability to penetrate the cell membrane fatty layer

31
Q

High solubility of barbiturates results in this drug

A

Ultra-short acting

Rapid tissue redistribution

32
Q

Moderate solubility of barbiturates results in this drug

A

Short-acting

33
Q

Which acting type (ultra short, short, long acting) drug is metabolized by the liver

A

Short-acting

34
Q

Which acting type (ultra short, short, long acting) drug is metabolized by the kidneys

A

Long acting

35
Q

Low lipid solubility results in this drug

A

Long acting

36
Q

Thiopental is given this route

A

IV

37
Q

You should not give repeated doses of this drug

A

Thiopental

38
Q

What are the effects of barbiturates on dogs with little fat?

A

Prolonged recovery

Drug lasts longer on the CNS

39
Q

Which category of drugs an cause sloughing of the tissues if given outside the vein?

A

Barbiturates

40
Q

The solution to pollution is what?

A

Dilution

41
Q

Chronic admin. of phenobarbital leads to this

A

Increased activity of the enzyme MFO, leading to tolerance

42
Q

MFO

A

Mixed Function Oxidase

43
Q

Don’t use Thiopental is this is present

A

Precipitate

44
Q

Avoid use of this drug in sight hounds

A

Thiopental

45
Q

Pentobarbital is largely replaced by this drug

A

Propofol

Anesthesia&Surgery (13 decks)

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