Inhibitors of Protein Synthesis Flashcards
1
Q
Inhibitor of Protein Synthesis
A
Anti-microbials that target protein synthesis of bacterial cells
Usually are bacteriostatic
2
Q
Tetracycline
A
4 rings = Tetra Reversibly binds to 30s subunit of ribosomes; blocks tRNA Broad Spectrum Bacteriostatic Lipophilic molecules Widely distributed ADRs: black hairy tongue, photosensitivity, dental staining Don't give to preg women or kids, DIs: Antacids i.e. tetracycline, doxycycline,
3
Q
Resistance Mechanisms
A
Disable = Abx degrading enzyme Disguise = Abx altering enzyme Discharge = Efflux Pump
4
Q
Macrolides
A
Binds to 50s subunit
Mild-to-moderate bacterial infx
Protein synthesis inhibitor
Active against atypicals, some gram (+)/(-)
Bacteriostatic
Erythromyocin: Gram (+) and Legionella
Azythromyocin (Zpack): Atypicals PNEUMONIA, Gram (+), Shigella
5
Q
DIs of Azythromyocin:
A
none to worry about; does NOT inhibit CYP450
6
Q
ADRs of Azythromyocin:
A
GI, hypersensitivity, secondary infections, prolonged QT interval
