Inhibitors of Bacterial Metabolism

Question 0

Sulfonamides spectrum

Answer 0

G+,-
UTI (E. coli)
Nocardiosis
Toxoplasmosis
Otitis media

Question 1

Sulfonamide drugs

Answer 1

sulfadoxine/pyrimethamine (Fansidar), 
sulfisoxazole, 
sulfadiazine, 
silver sulfa- diazine (Silvadene), 
sulfasalazine (Azaline, Azulfidine), 
trimethoprim (Proloprim), and 
trime- thoprim/sulfamethoxazole (Bactrim, Septra)

Question 2

Sulfonamides+Trimethoprine synthesis used for:

Answer 2

GI infections (Shigellosis)
prophylaxis for PCP (Pneumocystis Pneumonia)

Question 3

Long acting Sulfonamides
Used in combination with ____
To treat____

Answer 3

Sulfadoxine
Pyrimethamine
Used to treat Malaria (interferes with parasitic dihydrofolate reductase)

Question 4

Sulfrasalazine (poorly absorbed) used to treat:

Answer 4

Ulcerative colitis

Question 5

Silver Sulfadiazine (topical) used to treat

Answer 5

wound and burn infection

Question 6

Sulfonamides mechanism

Answer 6

Inhibits bacterial dihydropteroate reductase

Question 7

Trimethroprim mechanism of action

Answer 7

Inhibits bacterial dihydrofolate reductase

Question 8

Trimethoprim spectrum

Answer 8

H influenza

M catarrhalis