Cell Transcription/translation Inhibitors

Question 0

Gentamycin/Tobramycin are what class drugs?
What do they treat?

Answer 0

Aminoglycosides (block translation)

only Gram-
enterobacter
proteus
pseudomonas
klebsiella
serratia

Question 1

Aminoglycosides only work on what bacteria?

Why?

Answer 1

Gram Negative Aerobes

b/c it is a polycation that is taken up through ENERGY DEPENDENT PHASE 1 TRANSPORT (electron transport)

Question 2

Oral Neomycin used for what?

Answer 2

To treat hepatic encephalopathy

kills intestinal flora in order to prevent buildup of Ammonia

Question 3

Main toxicities of Aminoglycosides

Answer 3

Ototoxic (vestibular and cochlear)

Nephrotoxic

Question 4

Tetracyclines drugs

Answer 4

Tetracycline
oxytetracycline
demeclocycline
doxycycline
minocycline
tigecycline

Question 5

Tetracyclines DOC for…

Answer 5

Rickettsial infections:
Rocky Mountain spotted fever
Cholera
Lyme
Chlamydia
mycoplasma pneumoniae

H. pylori

Question 6

Tetracycline adverse effects

Answer 6

GI upset, possibility of superbug infections
hepatic damage
Dermatologic rxn
tooth discoloration
retard bone growth

Question 7

Chloramphenicol spectrum

Answer 7

Most G-:
Anaerobes
Clostridia
Chlamydia
Mycoplasma
Rickettsia

Typhoid
Meningitis

Question 8

Tetracycline of choice for people with impaired renal function

Answer 8

Doxycycline,

biliary excretion

Question 9

Erythromycin (macrolide) DOC for

Answer 9

Legionnaire’s Disease
Gram+:
Syphilis, Mycoplasma Pneumoniae, Diptheria, Bordetella Pertusses (whooping cough)

Question 10

Drug combination for Mycoplasma Pneumoniae infection in immunocompromised

Answer 10

Erythromycin, Clarithromycin, Azithromycin

Question 11

Clindamycin used for treatment of:

Answer 11

Abscesses from anaerobes (such as B. fragilis)