Cell wall inhibitors Flashcards
Penicillinase resistant penicillins
Nafcillin, oxacillin, dicloxacillin
Penicillin G and V effective against what G- cocci?
Gonococci and meningococci
Extended spectrum penicillins
Ampicillin(+sulbactum), Amoxacillin (+clavulanic acid)
Extended spectrum penicillin effective against what gram - rods?
Salmonella
H. Influenza
Proteus
Enterococcus
Antipseudomonal penicillin
Ticarcillin + clavulanic acid
Piperacillin
Ampicillin used for
Haemophilus influenzae, Streptococcus pneumonia, Streptococcus pyrogenes, Neisseria meningitides, Proteus mirabilis, and Enterococcus faecalis.
Sulbactum, tazaobactum are what?
What are they added to?
What coverage?
Beta lactamase inhibitors
Ampicillin, piperacillin
Gram negative, anaerobes, Pseudonomas
Used most for endocarditis prophylaxis
Amoxacillin and ampicillin
Mode of function of penicillin and cephalosporins
Inhibit bacterial Transpeptidase
Thus preventing cross linking if peptidoglycan polymers
First generation Cephalorsporins
Cephalexin (only one with ph)
Cefadroxil
Cefazolin
Second generation Cephalosporins
Cefaclor
Cefotetan
Cefoxitin
Cefuroxime
Third generation Cephalosporins
Ceftizoxime Cefotaxime Ceftriaxone Cefdinir Ceftazidime Cefixime Cefperazone Cefepime
Third generation Cephalosporins that are effective against Pseudomonas Aureginosa
Ceftazidime
Cefperazone
Only third generation Cephalosporins that are excreted through the biliary tract, thus effective for biliary infections
Ceftriazxone
Cefperazone
First generation cephalosporins used mainly for
G(-): Klebsiella and E. Coli
non-resistant UTI
Second generation cephalosporins mainly used for
Streptococcal E. Colil Klebsiella Anaeroes (except C. difficile) Proteus
UTI, respiratory, bone
Third generation cephalosporins effective against
Gram Negative:
Neisserias (Gonorrhea and Meningitis)
Coccoid rods: H. Influenza, Enterobacter
Rods: Salmonella, Proteus, Serratia, E. Coli
Number one cause of nosocomial C. difficile Colitis
Cephalosporin causing superinfection of G+ organisms
Aztreonam
Gram Negatives
Carbapenems include…
Imipenem, Meropenem, Ertapenem
Carbapenems coverage
Broad spectrum
(resistant to beta-lactamase)
penicillinase resistant S. Aureus E. Coli Klebsiella Enterobacter H. influenza
Vancomycin mode of action
Effective against
binds to elongating end of peptidoglycan to prevent further elongation
Resistant Gram + (MRSA)
C. difficile colitis
Neosporin formuation
Bacitracin, Polymixin, Neomycin
Effective against Vancomycin resistant strains
Daptomycin
