Drugs 2

Question 0

Chloramphenicol AE

Answer 0

Aplastic anemia and bone marrow suppression

Question 1

DOC for meningitis

Answer 1

Chloramphenicol

Excellent penetration of BBB

Question 2

Deficiency of glucose-6-phosphate dehydrogenase results in

Answer 2

Oxidative damage due to lack of glutathione

Results in hemolytic anemia

Question 3

Isoniazid ( INH) mechanism of action

Answer 3

Inhibit synthesis of mycolic acid required for mycobacteria tuberculosis cell wall

Question 4

Primaquine

Answer 4

Treats malaria

Clears hypnozoites, which are the dormant form found in liver

Question 5

Nitrofurantoin

Answer 5

Used in treating UTIs

Question 6

Phenytoin uses

Answer 6

For complex partial seizures
General tonic clonic seizures

And is a class IB antiarrhythmic

Works by blocking Na+ channels

Can cause megaloblastic anemia

Question 7

Methotrexate (MTX) mechanism

Answer 7

Inhibits folic acid synthesis by blocking
DIHYDROFOLATE REDUCTASE (DHFR)
Which mediates dihydrofolate->tetrahydrofolate

Question 8

Erythromycin class
Adverse effects

Answer 8

A macrolide (blocks protein synthesis by preventing tRNA transfer from A site to P site)

Acute hepatitis and jaundice
Torsades de pointes

Question 9

Ampicillin mechanism

Answer 9

Blocks Transpeptidase enzyme. Prevents cell wall synthesis.

AE include pseudomembranous colitis

Question 10

Gynecomastia

Commonly caused by what drugs

Answer 10

Spiromolactone
Digitalis 
Estrogen
Ketoconazole (anti fungal)
Cimetidine (histamine H2 receptor blocker)

Question 11

Causes gout

Answer 11

Furosemide (loop diuretic)

Thiazide (diuretic, proximal tubulal)

Question 12

Cyclosporine

Function & mechanism

Answer 12

Prevents graft vs host disease

By inhibiting synthesis of IL2 thus suppressing CD8 activation

Question 13

Colchicine use

Answer 13

Treat gout

Question 14

Fibrates mechanism

Answer 14

Induces synthesis of Lipoprotein Lipase

Question 15

Statins mechanism

Answer 15

Competitive inhibitor of HMG-CoA Reductase

Inhibits cholesterol synthesis

Question 16

Tetracycline DOC for

Answer 16

Chlamydia
Rickettsia 
Spirochetes (syphillis)
Anthrax 
Plague

Question 17

Carbamazepine
Function
AE

Answer 17

Anticonvulsant
Mood stabilizing (ADHD, schizophrenia)

Steve Johnson’s rash
Agranulocytosis

Question 18

Lamotrigine function

Answer 18

Anticonvulsant

Mood stabilizer

Question 19

Only type of seizure phenobarbital is not used for

Answer 19

Absence seizures

Question 20

Cyclosporine main side effect

Answer 20

Nephrotoxicity

Question 21

Prostaglandin analog Abortifacients

Answer 21

PGE1: alprostadil
PGE2: dinoprostone
PGF2: carboprost

Question 22

Prostacycline is

Answer 22

PGI2
Platelet stabilizer
Vasodilator