Dynamics And Kinetics Flashcards
0
Q
Formula for volume of distribution
A
Vd = amount of drug in body / plasma drug concentration
1
Q
For IV dose bioavailability is
A
100%
2
Q
Vd is low, then distribution is in ____ and nature of drug is
A
In plasma/blood because it is large or charged and can’t penetrate into tissue
3
Q
Half life formula
A
T1/2 = (0.7xVd)/CL
CL = clearance
4
Q
Drug metabolism phase I
A
Reduction, oxidation, hydrolysis
By p-450
5
Q
Drug metabolism phase II
A
Conjugation:
Glucuronidation
Acetylation
Sulfation
Drug becomes completely inactive
6
Q
Therapeutic index
A
TILE
Therapeutic Index = LD50/ED50
High TI = safer drug
