Drugs 1 Flashcards
Nicotinic Ach receptors are
Ligand gated Na+/k+ channels
Parasympathetic always what kind of receptors?
Muscarinic
Muscarinic Ach are
G protein coupled receptors
Receptor causes increased heart rate
Beta 1 beta 2
Causes decreased heart rate
Muscarinic 2
Cause vasodilation, smooth muscle relaxation
Beta 2, dopamine 1
Cause smooth muscle contraction
Alpha 1 and vasopressin (angiotensin) 1
Bethanechol
Cholinomimetic
Activates Bowels and Bladder
Carbachol
Cholinomimetic
Carbon copy of acetylcholine
Pilocarpine
Cholinomimetic
You sweat, cry, and drool on your PILow
For open angle and closed angle glaucoma
Neostigmine
Anti choline-esterase
Treats: myasthenia gravi, ileus, urine retention
Pyridostigmine
Long acting on myasthenia gravis
Anticholineesterase
Physostigmine
Treats Anticholinergic toxicity
Crosses BBB
PHYxes atropine overdose
Anticholineesterase
Donepizil
Treats Alzheimer’s
Anticholineesterase
Cholinomimetic agents exacerbate
COPD, asthma, peptic ulcers
Organophosphates
Irreversibly bind AChE
Causes…
DUMBBELSS
Diarrhea Urination Miosis Bronchospasm Bradycardia Excitation of skeletal muscle Lacrimation Sweating Salivation
Benztropine
Parkinson’s disease
Park my Benz
Muscarinic antagonist
Scopolamine
Muscarinic antagonist
Motion sickness
Ipratropium, tiotropium
COPD, asthma
Muscarinic antagonist
Atropine
Action
Side effects
Muscarinic antagonist
ie antagonizes parasympathetic = sympathetic
Hot Dry Red Blind (cycloplegia) Mad (disorientation)
Difference between epinephrine and isoproterenol
NE is a Beta1 and alpha 1&2 agonist
IsoP is only B1&2 (iso Ball)
NE causes rise in BP and reflex bradycardia
IsoP causes lower BP and b1 induced tachycardia
Clonidine
Centrally acting a2 agonist
Decrease central sympathetic outflow
Treats hypertension
Non-selective alpha blockers
Phenoxybenzamine: for pheochromocytoma
Phentolamine
Alpha 1 selective blockers
Ends in -osin
Prazosin, terazosin, doxazosin, tamsulosin
Treats Hypertension, urinary retention
