Inhibition of DNA function PPT questions Flashcards
- Which statement about the fluoroquinolones is accurate?
A. Gonococcal resistance to fluoroquinolones may involve changes in DNA gyrase
B. A fluoroquinolone is the drug of choice for treatment of an uncomplicated UTI in a 7-year-old girl
C. Fluoroquinolones are contraindicated in patients with hepatic dysfunction
D. Most “first-time” uncomplicated urinary tract infections are resistant to ciprofloxacin
A.
m1.The FDA has advised against use of a fluoroquinolone to treat acute sinusitis, acute exacerbation of chronic bronchitis, and uncomplicated urinary tract infection because:
A. They are not effective for treatment of these infections
B. They can cause serious side effects
C. They increase bacterial resistance to antibiotics
D. None of the above
B
m2.The drug of choice for oral treatment of a first episode of mild to moderate C. difficile infection is:
A. Levofloxacin
B. Metronidazole
C. Vancomycin
D. Clindamycin
C. Vanco
- A 22-year-old man with gonorrhea is to be treated with ceftriaxone and will need another drug to provide coverage for urethitis caused by C. trachomatis. Which of the following drugs is LEAST likely to be effective in nongonococcal urethitis?
A. Azithromycin B. Moxifloxacin C. Erythromycin D. Nitrofurantoin E. Doxycycline
D
- Consumption of ethanol together with this drug causes nausea, vomiting, abdominal cramps, flushing, and headache in some patients.
A. Nitrofurantoin B. Metronidazole C. Disulfiram D. Doxycycline E. Erythromycin
B. Metro
Which antibacterial drug target is also present in humans?
A. 70S ribosome B. DNA gyrase C. 50S ribosomal subunit D. Dihydropteroate synthesis E. Dihydrofolate reductase
E. Dihydrate reduct
- Select the TRUE statement about sulfonamides?
A. Crystalluria due to sulfonamides is most likely to occur at higher urinary pHs
B. Kernicterus may occur in the newborn if sulfonamides are administered late in pregnancy
C. Sulfonamides are bactericidal
D. Sulfonamides inhibit bacterial dihydrofolate reductase
B
m3.A 30-year-old complains of urgency and burning during urination and asks if she can take ciprofloxacin, the drug that was prescribed for her the last time she had a urinary tract infection. You could tell her that ciprofloxacin:
A. Is no longer recommended for first-line empiric treatment of urinary tract infections
B. Can cause tendinitis and tendon rupture (occasional)
C. Can cause peripheral neuropathy (occasional)
D. Can cause CNS effects (rare)
E. All of the above
E
- Which of the following treatments for urinary tract infections acts via a bacteriostatic action?
A. Sulfamethoxazole B. Sulfamethoxazole-trimethoprim C. Nitrofurantoin D. Ciprofloxacin - uFQ E. Cephalexin - 1st C F. Amoxicillin - ePCN
A
m4.Which of the following would be a reasonable choice for first-line empiric treatment of community-acquired pneumonia in an adult with recent antibiotic exposure?
A. Oral vancomycin B. Levofloxacin C. Trimethoprim/sulfamethoxazole D. Cephalexin E. Ciprofloxacin
B
m5.Which of the following would be effective for empiric outpatient treatment of skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus?
A. Linezolid B. Clindamycin C. Doxycycline D. Trimethoprim-sulfamethoxazole E. All of the above
E.
- A 22-year-old female presents with a 2-day history of dysuria with increased urinary frequency and urgency. A urine culture and urinalysis are done. She is diagnosed with a urinary tract infection caused by E. coli. All of the following would be considered appropriate therapy for this patient EXCEPT:
A. Levofloxacin - urFQ
B. SMX-TMP
C. Nitrofurantoin
D. Cephalexin
A
- A 27-year-old woman develops an exfoliative rash along with painful joints, anemia, and nephritis while being treated for a first episode of a urinary tract infection. Which of the following drugs is most likely responsible for these effects?
A. Sulfamethoxazole-trimethoprim B. Nitrofurantoin C. Ciprofloxacin D. Metronidazole E. Gentamicin
A
