Antiplatelet drugs Flashcards

1
Q

What antiplatelets work by inhibition of platelet ADP (P2Y12) receptor? Which ones are irreversible and which one is reversible?

A

Clopidogrel and prasurgrel are irreversible

Ticagrelor is reversible binding

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2
Q

What antiplatelet works by inhibition of phosphodiesterase in platelets? this inhibiton increases cAMP which increases PGI2 anti-aggregation effect

A

Dipyridamole

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3
Q

What antiplatelets block platelet GIIb/IIIa receptor preventing fibrinogen binding and platelet aggregation?

A
  1. Abciximab- monoclonal antibody
  2. Eptifibatide- cyclic peptide
  3. Tirofiban- non-peptide
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4
Q

How often is Clopidogrel and prasurgrel taken?

A

once daily

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5
Q

how often is ticagrelor taken?

A

PO BID

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6
Q
  1. how are Abciximab, Eptifibatide, Tirofiban administered?
A

parenteral

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7
Q

How is aspirin eliminiated?

A

hepatic

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8
Q

how is clopidogrel eliminated?

A

well its activated by CYP2C19 then renal and fecal elimination

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9
Q

How is Prasugrel eliminated?

A

Well its activated by CYP3A4/2B6 thats all we know

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10
Q

How is Ticagrelor eliminated?

A

CYP3A4 metabolism to active metabolite

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11
Q

how are Abciximab, Eptifibatide, Tirofiban eliminated and list them in order of least half life time to greatest.

A
  1. renal elimination

2. A

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12
Q

how is dipyridamole eliminated?

A

hepatic: Phase II conjugation

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13
Q

Adverse effect of aspirin?

A
  1. gastric upset

2. bleeding

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14
Q

Adverse effect of clopidogrel, ticagrelor, prasurgel.

A
  1. Bleeding ([P]-[T]>[C])
  2. clopidogrel causes dyspepsia, gastritis and headache
  3. ticagrelor causes dyspnea, bradyarrhythmias
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15
Q

what adverse effect dose Abciximab, Eptifibatide, Tirofiban have

A

Bleeding

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16
Q

Which antiplatelet might have its activation of prodrug blocked if taken with a PPI

A

Clopidogrel

17
Q

true or false: Prasugrel has a DDI with PPI

A

false

18
Q

use for aspirin?

A
  1. Acute MI
  2. unstable angina
  3. ACS
  4. PCI
  5. secondary prevention of MI-Stroke
19
Q

uses of ticagrelor, clopidogrel, and prasugrel?

A
  1. Acute MI-unstable angina

2. PCI

20
Q

which is best for secondary prevention of MI?

A

Dipyridamole

21
Q

which ones would you use for PCI and PCI only?

A

Abciximab, Eptifibatide, Tirofiban