Anticoag drugs from table Flashcards
What is heparins MOA?
Heparin binds to ATIII and inactivates IIa and Xa
What is enoxaparin and dalteparin MOA?
enoxaparin and dalteparin which are low molecular weight heparin bind to ATIII and inactivate Xa
What is Warfarins MOA
Warfarin inhibits the livers production of Vit K- deep factors (II, VII, IX, and X)
What is Dabigatrans MOA?
da big one, dabigatran is a direct thrombin IIa inhibitor
What is Rivaroxaban and Apixabans MOA
They have their MOA in the name. They both directly inhibit factor Xa
Which anticoag has the fastest onset of action and which one has the slowest?
Heparin is the fastest, wafarin in the slowest
Which anticoag is not safe in pregnancy?
Warfarin
Which anticoags dont require renal dosing?
heparin and warfarin
Rifampin and dronedarone will have what effect on dabigatran, xarelto, and eliquis
These drugs are P-glycoprotein inducers which decrease the effect of the anticoags
What is the overdose treatment for dabigatran?
idarucizumab
What is the overdose treatment for eliquis and xarelto?
andexanet alfa
Which drugs are eliminated by hepatic mechanisms?
Warfarin, Xarelto and Eliquis
Which has a longer duration of action, heparin or LMWH?
LMWH- once to twice daily dosing and is eliminated by first order renal mechanism
Which has a greater chance of thrombocytopenia? Heparin or LMWH
That would be heparin
What is the overdose treatment for heparin and LMWH
Protamine
