Inhibition

Question 1

What is inhibition?

Answer 1

Enzyme activity can be premed by enzyme inhibitors- molecules that bind to the enzyme that they inhibit

Question 2

What does a competitive inhibitor do?

Answer 2

-

Question 3

What affects how much the enzyme in inhibited by competitive inhibition?

Answer 3

Depends on the relative concentrations of the inhibitor and the substrate

Question 4

What happens if there is a high concentration of the inhibitor in competitive inhibition?

Answer 4

Take up nearly all the active sites and hard,y any of the substrate will get to the enzyme

Question 5

What happens if there is a higher concentration of the substrate in competitive inhibition?

Answer 5

The substrates chances of getting to an active site before the inhibitor increase so increasing the concentration of substrate will increase the rate of reaction

Question 6

What happens in non-competitive inhibition?

Answer 6

-

Question 7

Why don’t non competitive inhibitors compete with the substrate mol fuels to bind to the active site?

Answer 7

Because they are a different shape

Question 8

What will happen if you increase the concentration of substrate in non-competitive inhibitors?

Answer 8

Won’t make any difference to the reaction rate- enzyme activity will still be inhibited

Question 9

What is irreversible inhibition?

Answer 9

Strong, covalent bonds, the inhibitor can’t be removed easily

Question 10

What is reversible inhibition?

Answer 10

Weak hydrogen or ionic bonds the inhibitor can be removed

Question 11

What is end-product inhibition?

Answer 11

When the final product in a metabolic pathway inhibits an enzyme that acts earlier on in the pathway