Information Processing Flashcards
Pathway of information in neurons
Dendrites: intake of information
Nucleus: information processing
Axon: transport/ conduction of information
Presynaptic terminal: information transfer
Synapses
weakening/strengthening and integration of signals
electrical
chemical
Electrical Synapses
Gap junction No transmitter, controlled by charge Close membranes, connected by ion pipe Synchronization of cells with same function Reciprocal, without delay, no processing
Chemical
Neurotransmitter to synaptic cleft, only one direction
Slower, but complex signal processing
Structure of chemical synapses
Presynaptic terminal (Mitochondria, Vesicles with neurotransmitter, sending neuron)
Synaptic cleft
Subsynaptic membrane as part of postsynaptic membrane (receptors)
Transfer at chemical synpase
AP coming in at presynaptic terminal -> dumping of neurotransmitter in synaptic cleft
NT reaching receptor -> change of permeability -> potential shift
Amount of transmitter binding if inhibiting or exciting
Principles of neurotransmitter
Short distance, only between two cells via dendrites
Vesicles
From Golgi-apparatus -> fusion with cell membrane -> into synaptic cleft
Main and co-transmitters
Calcium Ions
Release of neurotransmitters only if enough CA2+ in extracellular fluid
AP -> new membrane potential at presynaptic terminal -> CA2+ channels opening -> CA2+ coming in -> if enough intracellular fluid fusion of vesicles and cell membrane
Receptors and ligands
Change in shape when binding
One to many, many to one affinity
Medicines similar sjape
Ligand-gated ion channels
Direct, type I, building own ion channel
Conformation change to open by NT
Selective, fast (sensory and motor system)
Metabotropic receptors
slower, but more variable
Indirect, type II
G Protein attached to Membran protein on inside -> NT binding with protein -> open channels
Auto receptors
Presynaptic membrane
Feedback (own transmitter release)
Chemical characteristics of NT
Monoamines
Amino Acids
Peptides
Acetycholin
Excitatory transmitter in PNS
important in motor function, vegetative system, glands