Influence of renal insufficiency on drug elimination and response

Question 1

What are pharmacokinetics?

Answer 1

How the body handles drugs

Question 2

What are pharmacodynamics?

Answer 2

How tissue responds to drugs

Question 3

What are the criterion used for impaired renal function?

Answer 3

Narrow range drugs

Drugs that are dependent on renal elimination

Question 4

What are narrow range, renally eliminated drugs?

Answer 4

Digoxin (patients with renal dysfunction

Lithium (used in bipolar disorder and lots of attention to renal function must be paid)

Hypoglycaemics (insulin is substantially removed by kidneys in a complex manner)

Methotrexate (an anticancer drug)

Aminoglycoside antibiotics