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General Pathology > Inflammatory mediators > Flashcards

Inflammatory mediators Flashcards

1
Q

sialyl-lewis X modified glycoprotein binds to

A

E and P selectin

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2
Q

integrin binds to

A

ICAM 1

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3
Q

what are exogenous chemical mediators of inflammation

A

endotoxins

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4
Q

what are endogenous mediators of inflammation

A

plasma, leukocytes, endothelial cells, fibroblasts

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5
Q

vasodilation is caused by

A

prostaglandins, NO

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6
Q

increased vascular permeability is caused by

A

histamine, serotonin, C3a, C5a, bradykinin, leukotriens, PAF

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7
Q

chemotaxic leukocyte activation is caused by

A

C5a, LTB, chemokines

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8
Q

fever is caused by

A

IL-1, IL6, TNF , prostoglandins

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9
Q

pain is caused by

A

prostaglandins, bradykinin

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10
Q

the first mediators to be released during inflammation are

A

histamine and serotonin

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11
Q

effect of histamine

A

binds to H1 receptors on microvasclar endothelial cells , and dilates arteriols and increases venules permeability

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12
Q

effect of serotonin

A

increased vascular permeability

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13
Q

products of the cyclooxygenase pathway are

A

thromboxane, prostacyclin, prostaglandin

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14
Q

thromboxane function

A

platelet aggregation and vasoconstriction

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15
Q

prostacyclin function

A

inhibits platelet aggregation, allows vasodiltion

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16
Q

prostaglandin function

A

vasodilation and increased permeability

17
Q

what makes lipoxins

A

12-lipooxygenase

18
Q

what is the function of lipoxins

A

inhibit leukocyte recruitement. resolve inflammation

19
Q

how are lipoxins formed

A

neutrophils produce LTA4 which is converted to lipoxins by platelets

20
Q

explain anti-inflammatory drugs COX inhibitors

A

(aspirin) NSAIDS. side effects are peptic ulcers.

21
Q

explain anti-inflammatory drugs COX2 selective inhibitors

A

cause increased risk of CV, CV events due to inhibition of PGI2 by endothelial cells, while TXA2 remains

22
Q

aspirin promotes x production

A

lipoxin

23
Q

NO is synthesized from

A

l-arginine

General Pathology (15 decks)

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