Inflammatory mediators Flashcards
sialyl-lewis X modified glycoprotein binds to
E and P selectin
integrin binds to
ICAM 1
what are exogenous chemical mediators of inflammation
endotoxins
what are endogenous mediators of inflammation
plasma, leukocytes, endothelial cells, fibroblasts
vasodilation is caused by
prostaglandins, NO
increased vascular permeability is caused by
histamine, serotonin, C3a, C5a, bradykinin, leukotriens, PAF
chemotaxic leukocyte activation is caused by
C5a, LTB, chemokines
fever is caused by
IL-1, IL6, TNF , prostoglandins
pain is caused by
prostaglandins, bradykinin
the first mediators to be released during inflammation are
histamine and serotonin
effect of histamine
binds to H1 receptors on microvasclar endothelial cells , and dilates arteriols and increases venules permeability
effect of serotonin
increased vascular permeability
products of the cyclooxygenase pathway are
thromboxane, prostacyclin, prostaglandin
thromboxane function
platelet aggregation and vasoconstriction
prostacyclin function
inhibits platelet aggregation, allows vasodiltion
prostaglandin function
vasodilation and increased permeability
what makes lipoxins
12-lipooxygenase
what is the function of lipoxins
inhibit leukocyte recruitement. resolve inflammation
how are lipoxins formed
neutrophils produce LTA4 which is converted to lipoxins by platelets
explain anti-inflammatory drugs COX inhibitors
(aspirin) NSAIDS. side effects are peptic ulcers.
explain anti-inflammatory drugs COX2 selective inhibitors
cause increased risk of CV, CV events due to inhibition of PGI2 by endothelial cells, while TXA2 remains
aspirin promotes x production
lipoxin
NO is synthesized from
l-arginine