Inflammatory mediators

Question 1

sialyl-lewis X modified glycoprotein binds to

Answer 1

E and P selectin

Question 2

integrin binds to

Answer 2

ICAM 1

Question 3

what are exogenous chemical mediators of inflammation

Answer 3

endotoxins

Question 4

what are endogenous mediators of inflammation

Answer 4

plasma, leukocytes, endothelial cells, fibroblasts

Question 5

vasodilation is caused by

Answer 5

prostaglandins, NO

Question 6

increased vascular permeability is caused by

Answer 6

histamine, serotonin, C3a, C5a, bradykinin, leukotriens, PAF

Question 7

chemotaxic leukocyte activation is caused by

Answer 7

C5a, LTB, chemokines

Question 8

fever is caused by

Answer 8

IL-1, IL6, TNF , prostoglandins

Question 9

pain is caused by

Answer 9

prostaglandins, bradykinin

Question 10

the first mediators to be released during inflammation are

Answer 10

histamine and serotonin

Question 11

effect of histamine

Answer 11

binds to H1 receptors on microvasclar endothelial cells , and dilates arteriols and increases venules permeability

Question 12

effect of serotonin

Answer 12

increased vascular permeability

Question 13

products of the cyclooxygenase pathway are

Answer 13

thromboxane, prostacyclin, prostaglandin

Question 14

thromboxane function

Answer 14

platelet aggregation and vasoconstriction

Question 15

prostacyclin function

Answer 15

inhibits platelet aggregation, allows vasodiltion

Question 16

prostaglandin function

Answer 16

vasodilation and increased permeability

Question 17

what makes lipoxins

Answer 17

12-lipooxygenase

Question 18

what is the function of lipoxins

Answer 18

inhibit leukocyte recruitement. resolve inflammation

Question 19

how are lipoxins formed

Answer 19

neutrophils produce LTA4 which is converted to lipoxins by platelets

Question 20

explain anti-inflammatory drugs COX inhibitors

Answer 20

(aspirin) NSAIDS. side effects are peptic ulcers.

Question 21

explain anti-inflammatory drugs COX2 selective inhibitors

Answer 21

cause increased risk of CV, CV events due to inhibition of PGI2 by endothelial cells, while TXA2 remains

Question 22

aspirin promotes x production

Answer 22

lipoxin

Question 23

NO is synthesized from

Answer 23

l-arginine