Hemostasis

Question 1

hemostasis

Answer 1

is the stoppage of bleeding via formation of a hemostatic clot at the site of vascular injury

Question 2

both hemostasis and thrombosis involve

Answer 2

vascular wall, platelets, coagulation cascade

Question 3

von wilebrand factor causes

Answer 3

platelet aggregation and adhesion

Question 4

inhibition of coagulation is caused by

Answer 4

thrombomodulin, heparin, alpha2 macroglobulin

Question 5

coagulation is caused by

Answer 5

tissue factor, factor V, binding IXa, Xa

Question 6

what is primary hemostasis

Answer 6

platelet and vascular response to vessel injury

Question 7

secondary hemostasis

Answer 7

coagulation factors response to vascular injury— formation of a fibrin clot

Question 8

what forms the hemostatic plug

Answer 8

platelets

Question 9

bleeding disorders result from

Answer 9

a deficiency in vWF and glycoprotein Ib

Question 10

the extrinsic and intrinsic coagulation cascade converge on which factor?

Answer 10

10

Question 11

what receptors are for thrombin

Answer 11

PAR (protease activated receptors) which are GPCR.

Question 12

functions of plasmin

Answer 12

fibrinolysis, and inhibition of fibrin polymerization

Question 13

plasmin is activated by

Answer 13

plasminogen activators

Question 14

plasmin is inactivated by

Answer 14

alpha2-antitrypsin and plasminogen activator inhibitors

Question 15

Antiplatelet effects.

Answer 15

Prostacyclin (PGI2) and nitric oxide
(vasodilators and Inhibitors of
platelet adhesion and aggregation)
Adenosine diphosphatase:
degrades ADP and inhibit platelet
aggregation

Question 16

Anticoagulant effects

Answer 16

Membrane-associated heparin-like molecules
Thrombomodulin
Tissue factor pathway inhibitor