Inflammation Flashcards
Review of inflammation and the effect PA has on it
What is inflammation indicated by?
Heat, pain, redness, swelling, lesser function
What is acute inflammation?
Host defense, tissue repair and remodelling, metabolic adaptor
What is acute inflammation activated by?
Microbes, cytokines, chemokines, lipids, bacterial peptides
What does acute inflammation activate?
Macrophages which secrete proinflammatory cytokines
What is IL-1ra
A receptor antagonist; defense system against IL-1
What is chronic inflammation?
Cellular dysfunction, tissue destruction/fibrosis, cachecia/metabolic syndrome
What is chronic inflammation activated by?
Microbes, cytokines, chemokines, lipids, bacterial peptides, sepsis and critical illness, muscular contraction
What is the acute effect of PA on inflammation?
Single bout of PA induces a transient increase in inflammatory signalling in tissue (e.g. IL-1); absence of TNF-alpha removed some of the tissue mayhem; IL-1ra counteracts tissue effects of IIL-1
What is PA inflammation essential for?
Muscle cell growth, activation and repair
What is the chronic effect of PA on inflammation?
Overtraining leads to persistent acute inflammatory stimuli
How is PA a useful anti-inflammatory adjunct therapy?
Regular PA decreases baseline levels of inflammation and magnitude of transient inflammatory response to PA
What are some chronic inflammatory diseases?
Diabetes: characterised by systematic inflammation; low-grade
What are some chronic high grade diseases?
Severe diabetes, arthritis, colitis
