Inflammation Flashcards
What is Inflammation?
- Latin, Inflamatio, to set on fire
- Biological reaction to noxious stimuli such as microbes, burns and trauma
- Fundamentally protective process but may potentially be harmful leading to tissue injury
What are the two types of inflammation?
- Acute inflammation
- Chronic Inflammation
What are the 5 clinical signs of acute inflammation
- Rubor (redness)
- Tumour (Swelling)
- Calor (Heat)
- Dolor (Pain)
- Functio Laesa (Loss of function)
What is acute inflammation?
- Rapid host response to deliver leucocytes and plasma proteins such as antibodies to the sites of infection or tissue injury
Acute inflammation protects the body from further injury in response to what?
- Infections
- Trauma (blunt or penetrating)
- Burns/frostbite (thermal and chemical)
- Allergic reactions
- Tissue necrosis
How fast does acute inflammation occur and last?
- Occurs immediately and lasts hours-days
What reactions does acute inflammation consists of?
- Consists of vascular and cellular reactions
What are the three major components of acute inflammation? Explain them
- Vascular dilation- to increase blood flow
- Structure changes - in the microvasculature to allow plasma proteins and leukocytes to leave the circulation
- Emigration - of the leukocytes from the microvasculature, their accumulation in the injury site and their activation to eliminate the offending agent
What happens in Vascular reaction
- Vessel dilation and increased blood flow
- Leakage of plasma fluid and protein
- Leukocyte emigration and accumulation in the site of injury
What happens in vessel dilation and what is its purpose
- One of the earliest signs of acute inflammation - quick
- To increase blood flow
- Results in heat and redness (hyperaemia)
- Induced by the actions of several mediators on VSM: Histamine, Bradykinin, NO
What are the 3 mediators of vascular reactions?
- Histamine
- Bradykinin
- Nitric Oxide
What is the source and function of Histamine
- Source: Mast cells, basophils, platelets
- Function: Arteriole dilation, increased of venous permeability
What is the Source and Function of Bradykinin
- source: kinin system
- Function: Vasodilation, increase vascular permeability, pain
What is the source and function of Nitric oxide
- Source: Endothelial cells
- Function: Vasodilatation
What happens in Increased vascular permeability (leakage)
- A hallmark of acute inflammation
- Allow plasma fluid and protein to escape from the circulation into extracellular tissue
- The cause of oedema