Infectious Canine Hepatitis Flashcards
Which virus family?
Adenoviridae…Canine adenovirus 1. Important!!!
Is this a DNA or RNA virus?
dsDNA
Why is this virus able to stay in the environment?
Because it’s naked
Does this virus make inclusion bodies?
Yep—intranuclear ones as well as large paracrystalline arrays
What does this virus do to RBC?
Agglutinate them!
What conditions can this virus cause in the body?
Mostly starts with respiratory and if that’s not overcome, can lead to acute/chronic hepatitis!
Also causes ocular disease/brain inflammation and interstitial nephritis
What’s the host range?
dogs, wild canids, skunks and bears!
Most CAV-1 infections are symptomatic or asymptomatic?
Asymptomatic
What do most CAV-1 infections present as?
Undifferentiated respiratory disease…mild.
If not respiratory, what are the 3 syndromes associated with canine hepatitis?
1) peracute. dead within hours
2) acute. will have fever, depression anorexia, V and bloody D, PETECHIAL HEMORRHAGES in the gums and mm, jaundice. Can present as hepatitis here.
3) Mild disease that may be result of partial vaccine protection
Dog comes in with vomiting and blood diarrhea (unbeknownst to you, he has CAV-1). Which diseases should you be thinking of?
infectious canine hep
parvo
distemper
Dog comes in with vomiting and blood diarrhea (unbeknownst to you, he has CAV-1). You start to add Parvo/distemper/canine hep to your list of differentials. all of a sudden, you notice petechial hemorrhages in the gums and mm as well as some jaundice.
Which disease is at the TOP of you differentia list?
infectious canine hep
What other C/S are seen in severely affected animals?
along with the other symptoms listed, you’ll see tachycardia, LEUKOPENIA just like distemper and Parvo, prolonged clotting time and DIC!!!
What’s the pathogenesis of canine hepatitis?
the dog gets t from the environment. the virus enters the nasopharyngeal/oral and conjunct routes. infects the tonsils and payer’s patches where viremia then occurs and organs are infected causing hemorrhages and necrosis in the liver kidneys spleen and lungs
What is Blue Eye?
Characteristic of this disease. Corneal edema.
AB-AG complexes accumulating in small vessels of the ciliary body interfering with normal fluid exchange of the cornea
when do you see blue eye?
if you give CAV-1 vaccine and during convalescent stage of natural infection
is blue eye permanent?
no
do you get blue eye with CAV-2 vaccine?
nope
Which is better diagnostic for canine hep, PCR or serology?
PCR plus clinical signs
don’t use serology unless PAIRED since this is a common virus
what is the major source of transmission?
urine (for a long time!), poop, saliva
Two things that are special about the CAV-2 vaccine:
1) the attenuated vaccine offers shed-seeding in the environment which 2* immunizes other dogs–> herd immunity
2) doesn’t cause blue eye
why is this virus easily disinfected?
envelop BUT WITH those projected penton fibers
Dog comes in with bloody diarrhea and vomiting and leukopenia (DISTEMPER IS LYMPHOPENIA)…you immediately think Parvo but you’re not sure. Which 2 clinical signs other than V and D make you think it’s not Parvo?
petechial hemorrhages in the gums and jaundice due to the chronic hepatitis
