Infections Flashcards

1
Q

What is this?

What is its pathology?

A

Herpetic Whitlow

Viral infection of the finger by Herpes Simplex 1- HSV1

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2
Q

Who is hepetic whitlow common in?

What is its pathphysiology?

A

Dental / medical personnel

Commonly effects toddlers and preschool children

viral shedding occurs with vesicles forming bullae

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3
Q

What are the symptoms and signs of someone with herpetic whitlow?

A

Intense burning then erytherma, malaise

O/e= erytherma then small vesicular rash

over 2 weeks vesicles may merge to -> bullae

Fever and lymphadenitis

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4
Q

How is hepetic whitlow confirmed?

A

TZANK smear

Diagnosis confirmed by culture, antibody titers or Tzank smear

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5
Q

How is this treated?

What are the complictions?

A

1) Non operative and Acyclovir

standard tx- resolution 7-10 days

acyclovir may reduce time of symptoms

2) Operative = AVOID as- associated with superinfections, encephalitis and death!!

Complications include SUPERINFECTIONS- may require further antibiotics oral- pencillinase resistance for 7-10 days

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6
Q

What is this?

What is its incidence?

What is it’s pathology?

A

Paronychia

Most common hand infection- children and women (3:1 cf males)

Most commonly affects the thumb

Break in seal between nail fold and plate allows bacteria to gain entry- result of nail biting or manicures

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7
Q

What is the common organism in acute and chromic paronychia?

A

ACUTE

Adults- Staphyloccus aureus

Children/ Diabetics**-mixed oropharyneal **

CHRONIC

Candida albicans- common diabetics, often unresponsive to antibiotics

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8
Q

What are the causes of acute paronychia?

A

Nail biting

Manicures

Thumb sucking

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9
Q

What are the causes of Chronic paronychia?

What are the risk factors for developing chronic paronychia?

A

Occupational exposure to water and irrants acid/alkali

RF= Diabetes

Psorasis

Steroids

Retroviral drugs- Indinavir= HIV +ve pts.*

*Resolves on withdraw of medication

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10
Q

What is the role of the nail organ?

A

Adds Stability to finger tip as counterforce to finger pulp

Thermoregulation- glomus bodies of nail/ nail bed

Extended Percision Grip- opposing thumb/index nails to remove a splinter

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11
Q

What is the nail plate made of and how much does it grow?

Where does it grow from

A

Made of keratin

Grows 3mm/ month, faster in summer

fingernails row faster than toes ( finger nails 3-6 months to regrow, toes 12-18 months)

Growth part is under eponychium

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12
Q

What are the symptoms of acute paronychia?

A

Pain

Nail fold tenderness

Erytherma

Swelling

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13
Q

What are the symptoms of chronic paronychia?

A

RECURRENT Boats of low grade inflammation

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14
Q

What do you find on examination of

1) acute paronychia and 2) chronic paronychia?

A

1) acute= Fluctuant

Nail plate discolouration- green= pseudomonas

2) Chronic ( see pic)- Nail plate hypertrophy- fungal infection

Nail fold blunting and retraction after rpt boats of inflammation

Prominent transverse ridges on nail plate

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15
Q

What are your differential diagnosis of a person with acute paronychia?

A

Herpetic whitlow

Felon

Onychomycosis

Psorasis

Glomus tumour

Mucous cyst

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16
Q

How do you tx acute paronychia?

A

Non operative- > Swelling but no fluctation= Warm soaks, oral antibiotics ( augmentin/clindamycin) and avoid nail biting

_Operative= fluctuation= _ Incision and drainage with partial or total nail bed removal

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17
Q

How do you tx chronic paronychia?

A

Non operative- warm soaks, avoid finger sucking, topical antifungals ( miconazole)- rarely antibiotics effective

Operative = Marsupialization ( See pic)= Excision of 3mm dorsal eponychrium crescent shape down to level of Germinal matrix ) combine with nail plate removal =Heal by secondary intention

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18
Q

Decribe your operative teachnique for incision and drainage of an acte paronychia with partial nail removal?

A

Approach
Incision into sulcus between lateral nail plate and lateral nail fold

Technique

preserve Eponychial fold by placing materials (removed nail) between skin and nail bed

If abscess extends proximally over eponychium (eponychia), a separate counterincision is needed over the eponychium

Obtain gram stain and culture

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19
Q

What are the complications of paronychia?

A

Eponychia- spreads to eponychium

Run around infection- both lateral folds involved

Felon- spreads to volar pulp- I& D required

Flexor tenosynovitis- volar spreads to felxor sheath

Subungual abscess- floating nail

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20
Q

What is this?

How does it occur?

A

A Felon

Infection of the volar pulp of the fingertip

Local spread from paronychia

Penetrating injury/ needle stick

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21
Q

Describe the anatomy of the pulp?

A

multiple small compartments of subcutaneous fat separated by fibrous septae between the distal phalanx and dermis

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22
Q

What is the pathology of a felon?

A

Swelling and pressure within micro-compartments, leading to “compartment syndromes” of the pulp

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23
Q

What are the causative organisms?

A

Staphylococcus aureus- most common

Gram negative organism- immunosupressed

Eikenella corrodens- in diabetics

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24
Q

What are the symptoms of a felon?

What are the signs ?

A

Pain and swelling of the finger pulp

Tenderness on palpation of the pulp

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25
How do you tx a Felon?
**Operative- incision and drainage** Due to risk of finger tip compartment syndrome
26
Can you describe the technique of incision and drainage of a Felon?
Approach: Keep incision **distal to DIP crease** -T o prevent DIP flexion crease contracture and prevent extension into flexor sheath. **Mid lateral approach** - see picture below- Indicated for deep felons with no foreign body and not discharging. Incision on **ulnar side** for digits **2,3 and 4** and **radial** side for **thumb** and digit **5** (non-pressure bearing side of digit) **Longitudinal approach** ( see pic) most direct) Indicated for superficial felons, foreign body penetration or visible drainage . AVOID FISH MOUTH INCISIONS-\> unstable fonger pulp DOUBLE LONGITUDINAL or transverse incision - injury to digital nerve and artery
27
Can you describe the technique drainage of a Felon and what to avoid?
Avoid violating **flexor sheath** or **DIP joint** to avoid spread into these spaces **Aim to Break up septa** to decompress infection and prevent compartment syndrome of fingertip don't forget gram stain and cultures Leave wound open to allow drainage!
28
What are the complications of a felon?
Finger digitial tip necrosis Finger tip compartment syndrome Flexor tenosynovitis Osteomyelitis
29
What types of bites are common? Which cause infection? How does the patient present?
**Dog and cat bites** **Cat bites** more frequently -needle like teeth -\> deep penetration wound so high suspicion required PC:Pain/swelling Wound to arm/ hand local or systemic sepsis
30
What are the common pathogens?
**Pasterella Multicoida**- 80% pt with **cat** bites Staph aureus Streptococcus alpha haemolytic Bacteriodes Corynebacterium
31
What is the pathology of dog and cat bites?
Dog bites- Cause **crush, puncture, avulsion, tears** and **abrasions** large dogs' jaws exert \>450lbs/ square inch more likely to cause **structural damage to nerves, vessels, joints** **Cats have fine sharp teeth-\> pentrating joints.** Puncture wounds that **close immediately-\> septic arthritis and osteomyelitis**
32
What is the treatment of a cat/dog bite?
Thorugh cleaning of wound with saop or iodine - shown to dramatically reduce the devlopement of rabies in those bitten by infected animals ## Footnote **_Non op_** Copious irrigation, appropriate antibiotics, tetanus and rabies prophylaxis Antibiotics- amoxicillin/clavulanic acid effective against Pasteurella multocida, ce furoxime or ceftriaxone **Surgical debridment** if crush/devitialised tissue, abscess, bites to pup space, flexor tendon, joinspace, deep space of hand, septic arthritis.
33
What is rabies?
Caused by a **rhabdovirus** common animal carriers include dogs, raccoons, bats, foxes Increased risk with open wounds, scratches/abrasions, mucous membranes fatal bites associated with large aggressive dogs, small children, head and neck bites prophylaxis is = human diploid cell vaccine and human rabies immunoglobulin Immobilise limb and elevate
34
What is the incidence of human bites?
Males more affcted then females Often occur around 3/4th MC after a fight- from direct punch another individual Actual human bite
35
What is the pathology of a fight bite?
Tooth pentrated capsule of MCPJ bacteria flora from mouth enter joint-\>infection Bacteria get trapped in joint as it is flexed and caught unde extensor tendon
36
What organisms are common in human bites?
Alpha haemolytic strep \* Staph aureus\* **Eikonella corrodens in 7-29%** \*= most common
37
What other pathology is associated with fight bites?
Extensor tendon lacerations
38
What are the signs and symptoms of a fight bite? What invetsigations would be orderd?
1) Pain, swelling to hand with puncture wound to 3/4 MC Purulent discharge Pain with passive and active rom Test flexor and extensor tendons 2) xray hand to exclude any foreign bodies- teeth!
39
What is the TX for fight bites?
**Operative- Incision and drainage** **Debridement of wound** **Open capsule** **Leave wound open for drainage** **Gram stain and culture** Iv antibotics for 48 hrs then change to oral for 5-7 days -target organism - amoxicillin/clavulanic acid (augmentin)
40
What is this ?
**Pyogenic flexor tenosynovitis** Infection of the **synovial sheath** that surrounds the flexor tendon
41
What is the pathology of flexor sheath infections?
1) **Penetrating injury** 2) **Spread** from felon, deep space infection, septic arthritis
42
What are the organims involved in flexor sheath infections?
**Staphylococcus aureus**- most common **Gram negative/ ****Anaerobic bacteria**= assoc HIV/ diabetic/ MRSA infections/ farmyard/ animal bites
43
What are flexor sheath infections commonly associated with?
**Horseshoe abscess** ## Footnote Many individuals have a connection between the sheaths of the thumb and little fingers at the level of the wrist I nfection in one finger can lead to direct infection of the sheath on the opposite side of the hand resulting in a condition known as a "horseshoe abscess'
44
Can you draw the flexor tendon sheaths? Can you describe their role
See pic below Tendon sheaths **function to allow glide of tendons, provide nutrtion by bathe in synovial fluid** and **protect** the **flexor tendons** They extend **DIPJ- midpalm** in **index, middle and ring fingers** **From DIPJ to wrist ( ulna bursa) in little finger** **from IPJ to wrist ( radial bursa) in thumb**
45
What are the signs of a flexor sheath infection?
**Kanavel signs** - 4 signs in total ## Footnote 1) **Flexed position** of involved digit 2) **Fusiform swellling** of digit 3) **Tenderness** to palpation over tendon sheath 4) Marked **Pain on passive stretch/extension**
46
What are the normal sypmtoms of a flexor sheath infection?
**Increase pain** 48 hrs- localised to palmar aspect of digit ## Footnote **Swelling**
47
Is imaging helpful in flexor tenosynovitis?
Xrays no use MRI cannot distinguish infectious flexor tenosynovitis from inflammatory but may help determine the extent of the ongoing process
48
What is the treatment of flexor tenosynovitis?
_Non op_: in **early intervention**= Admit, elevation and iv antibiotics, close obeservation- surgery if no improvement in 24hrs _Surgery_= incision and drainage of flexor sheath iv antibiotics following op to avoid **ADHESIONS** in flexor tendons
49
Describe the technique for closed drainage of flexor tenosynvoitis?
_**Palmar incision**: _ - transverse incision is made just **proximal to distal palmar crease,** over the infected tendon; - spread thru the palmar aponeurosis; - make incision just **proximal to A1 pully** and enter into sheath; _**Distal incision:** _ - finger incision may be made either dorslateral at level of middle phalanx or directly on palmar surface at this level; - incision can also be made in the **distal flexor crease** of digit; - distal sheath is exposed thru ulnar midaxial incision & opened; - enter sheath between **annular pulleys**, **insert small paeds feeding **catheter- (size no. 5 Fr) or 16 gauge catheter and irrigate +++ Iv antibiotics for 48 hrs then oral 2 weeks Hand physio post to prvent adhesions
50
What is the treatment if need to open tendon sheath?
Brunner lines in finger to open skin then incise tendon sheath prox A1 pulley and annular pulleys distally According to Hand Surgery Update 3 2003, Trumble states, open sheath irrigation has been replaced largely by closed sheath irrigation. These authors cite a retrospective study that showed **no statistical difference in resolution of infection using open sheath irrigation or closed sheath** irrigation, however, there was a trend towards more **frequent complications** and reoperations in the **open** drainage group.
51
What is this? Where can these be located?
possibly a **Deep space infection** **Hypothenar, Thenar and Midpalmar space** other DD not in this picture **Collar button infection- ( abscess in webspace between fingers)**
52
Can you describe the thenar, midpalmar and hypothenar spaces?
Thenar= A bursa (potential space) just palmar to **adductor pollicis** and dorsal to flexor tendons. Separated from midpalmar potential space by a fascial septum Midpalmar= dorsal and radial to hypothenar space Hypothenar space= palmar to 5th MC, dorsal and radial to hypothenar fascia, ulnar to hypothenar septum
53
Which space is commonly infected in deep infections? What are the signs and symtpoms?
**Thenar** hx of penetrating injury to hand Worsening swelling and pain O/E pain on thumb flexion- thenar space finger pain on little finger flexion- hypothenar pain on flexion middle, ring index- midpalmar
54
What is the treatment of deep palmar infection?
_Operative-_ incision and drainage ## Footnote Technique Use volar and dorsal incisions for collar button abscesses Avoid skin in actual web space **Thenar space** release- dorsal incision (can spread to involve 1st dorsal interossei) or palmar incision **Midpalmar release**- **transverse incision across palm** **webspace infection- incisions dorsal and volar to alow adequate drainage. Not transverse -\> contractures**
55
Who do Atypical mycobacterium infections affect? What is the location of the infection?
Marine workers Hand and wrist in 50% of cases
56
What is the pathophysiology of atypical mycobacterium?
Incubation period 2 weeks to 6 months Average time to diagnosis and tx is 1 year
57
What are the types of organism causing atypical myocbacterium infections?
**Mycobacterium marium**\*- injuries in marine environments/aquariums **mycobacterium avium**-intracellulare\* \*most common **M. kansasii** - i soil
58
Describe the signs and symptoms of atypical mycobacterium infection? How is it diagnosed?
Symptoms:cutaneous rash with discomfort signs: papules, ulcers and nodules- indistinguishable to tuberculous mycobacterial infection Dx by Culture requiring **Lowenstein-Jensen culture agar at 30-32 degrees**
59
How is atypical mycobacterium treated?
_NON OP _If diagnosed early with **ethambutol,** **tetraycline**, **trimethoprim-sulfamethoxazole**, **clarithromycin, azithromycin ** add rifampin if osteomyelitis present surgical debridement and antibiotics for later disease
60
What is this? What is the incidence?
Fungal infection serious in immunocompromised patients Rare but common to have it in areas of macerated skin.
61
Fungal infectsions can be divided into 3 caterogeries, what are they?
**Cutaneous** - involving nail bed-**Onychomycosis** **Subcutaneous** - **sporothrix schenckii** from rose thorn prick **Deep**-orthopaedic manifestation= tenosynovial septic arthritis, osteomyelitis
62
What is this? What causes it?
**Onychomycosis** A Superficial fungal infection of the nail **Trichophyton rubrum**=\>a destructive nail plate infection **Candida**=\>chronic infection of nail fold
63
How is Onychomycosis treated?
**Topical antifungals** **Nail plate removal** systemic **griseofulvin** or **ketoconazole** if retractible disease
64
What is this infection? What causes it ?
**Sporothrix schenckii** A common soil bacteria Rose thorn in classic mechanism of subcutaneous transmission
65
What are the signs of Sporothrix schenckii? How is diagnosis confirmed?
A small papule where pentration of skin made then additional lesions in region of lymphatic tissue ( see pic) ## Footnote S schenckii is isolated at room temperature on **Sabouraud dextrose agar**
66
How is Sporothrix schenckii treated ?
Oral **itraconazole** for **3 to 6 months**
67
Can you name any fungi that cause deep infections?
**Histoplasmosis**-\> sublclnical symptoms/ tenosynoval - found in rivers-tx amphotercin B, surgical debridment and tenosynovectomy **Coccidiomycosis- \> arthritis/synovitis/ periarticular arthritis** **tx with amphocterin B and surgical debridement **