Infection - Penicillins

Question 1

which drugs are narrow spectrum penicillin (beta lactamase sensitive)

Answer 1

• phenoxymethylpenicillin
• penicilin G benzylpenicillin

Question 2

is narrow spectrum penicillin (beta lactamase sensitive) gastric acid safe?

Answer 2

• phenoxymethylpenicillin = gastric safe
• penicilin G benzylpenicillin = not gastric safe only parental route

Question 3

what are broad spectrum penicillin (beta lactamase sensitive)?

Answer 3

• amoxicilin
• co-amoxiclav (amox + clavulanic acid)

co-amox = beta lactamse resistant

Question 4

broad spectrum penicillin side effects

Answer 4

• diarrhoea
• maculopapular rashes commonly occur in pt = glandular fever x use broad spec in sore throats blindly

Question 5

which is drug is penicillinase resistant penicilin

Answer 5

flucloxacillin

Question 6

is flucloxacillin with or without food?

Answer 6

empty stomach = 1hr before food/ 2 hours after food

Question 7

what does flucloxacilin cause?

+ risk factors

Answer 7

• cholestastic jaundice + hepatitis = v rare but up to 2 MT POST TX
• risk factors include tx for more than 2wk and higher age

Question 8

examples of antipseudomonal penicillin

Answer 8

• piperacillin (only available with) + tazobactam
• ticarcillin (only available with) + clavulanic acid

Question 9

s/e of penicillins

Answer 9

• enecephalopathy (fatal) x give intrathecathy
• true allergy rashes or anaphylactic
• not true allergy minor rashes, small, hot, itchy + con-confluent or rash after 72hr
• cross sens - x give cephlasporins